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Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
In some malignant tumours, the changes in neutrophil counts in relation to other blood cells are connected with unfavourable prognosis. Nevertheless, the prognostic value of the combinations of the haematological components in glioblastoma (GBM) remains under dispute. The clinical significance of th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225636/ https://www.ncbi.nlm.nih.gov/pubmed/35743468 http://dx.doi.org/10.3390/jcm11123397 |
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author | Jarmuzek, Pawel Kot, Marcin Defort, Piotr Stawicki, Jakub Komorzycka, Julia Nowak, Karol Tylutka, Anna Zembron-Lacny, Agnieszka |
author_facet | Jarmuzek, Pawel Kot, Marcin Defort, Piotr Stawicki, Jakub Komorzycka, Julia Nowak, Karol Tylutka, Anna Zembron-Lacny, Agnieszka |
author_sort | Jarmuzek, Pawel |
collection | PubMed |
description | In some malignant tumours, the changes in neutrophil counts in relation to other blood cells are connected with unfavourable prognosis. Nevertheless, the prognostic value of the combinations of the haematological components in glioblastoma (GBM) remains under dispute. The clinical significance of the neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) was investigated in our study. We retrospectively studied 358 patients (males n = 195; females n = 163) aged 59.9 ± 13.5 yrs with newly diagnosed glioma and admitted to the Neurosurgery Centre. Routine blood tests and clinical characteristics were recorded within the first hour of hospital admission. The inflammatory variables: NLR, SII and SIRI exceeded the reference values and were significantly elevated in Grade 3 and Grade 4 tumour. The Cox model analysis showed that the age ≥ 63 years, NLR ≥ 4.56 × 10(3)/µL, SII ≥ 2003 × 10(3)/µL and SIRI ≥ 3.03 × 10(3)/µL significantly increased the risk of death in Grade 4 tumour patients. In the inflammatory variables, NLR demonstrated the highest impact on the survival time (HR 1.56; 95% CI 1.145–2.127; p = 0.005). In the first Polish study including GBM patients, the age in relation to simple parameters derived from complete blood cell count were found to have prognostic implications in the survival rate. |
format | Online Article Text |
id | pubmed-9225636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92256362022-06-24 Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study Jarmuzek, Pawel Kot, Marcin Defort, Piotr Stawicki, Jakub Komorzycka, Julia Nowak, Karol Tylutka, Anna Zembron-Lacny, Agnieszka J Clin Med Article In some malignant tumours, the changes in neutrophil counts in relation to other blood cells are connected with unfavourable prognosis. Nevertheless, the prognostic value of the combinations of the haematological components in glioblastoma (GBM) remains under dispute. The clinical significance of the neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) was investigated in our study. We retrospectively studied 358 patients (males n = 195; females n = 163) aged 59.9 ± 13.5 yrs with newly diagnosed glioma and admitted to the Neurosurgery Centre. Routine blood tests and clinical characteristics were recorded within the first hour of hospital admission. The inflammatory variables: NLR, SII and SIRI exceeded the reference values and were significantly elevated in Grade 3 and Grade 4 tumour. The Cox model analysis showed that the age ≥ 63 years, NLR ≥ 4.56 × 10(3)/µL, SII ≥ 2003 × 10(3)/µL and SIRI ≥ 3.03 × 10(3)/µL significantly increased the risk of death in Grade 4 tumour patients. In the inflammatory variables, NLR demonstrated the highest impact on the survival time (HR 1.56; 95% CI 1.145–2.127; p = 0.005). In the first Polish study including GBM patients, the age in relation to simple parameters derived from complete blood cell count were found to have prognostic implications in the survival rate. MDPI 2022-06-13 /pmc/articles/PMC9225636/ /pubmed/35743468 http://dx.doi.org/10.3390/jcm11123397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jarmuzek, Pawel Kot, Marcin Defort, Piotr Stawicki, Jakub Komorzycka, Julia Nowak, Karol Tylutka, Anna Zembron-Lacny, Agnieszka Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study |
title | Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study |
title_full | Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study |
title_fullStr | Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study |
title_full_unstemmed | Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study |
title_short | Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study |
title_sort | prognostic values of combined ratios of white blood cells in glioblastoma: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225636/ https://www.ncbi.nlm.nih.gov/pubmed/35743468 http://dx.doi.org/10.3390/jcm11123397 |
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