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Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study

In some malignant tumours, the changes in neutrophil counts in relation to other blood cells are connected with unfavourable prognosis. Nevertheless, the prognostic value of the combinations of the haematological components in glioblastoma (GBM) remains under dispute. The clinical significance of th...

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Autores principales: Jarmuzek, Pawel, Kot, Marcin, Defort, Piotr, Stawicki, Jakub, Komorzycka, Julia, Nowak, Karol, Tylutka, Anna, Zembron-Lacny, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225636/
https://www.ncbi.nlm.nih.gov/pubmed/35743468
http://dx.doi.org/10.3390/jcm11123397
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author Jarmuzek, Pawel
Kot, Marcin
Defort, Piotr
Stawicki, Jakub
Komorzycka, Julia
Nowak, Karol
Tylutka, Anna
Zembron-Lacny, Agnieszka
author_facet Jarmuzek, Pawel
Kot, Marcin
Defort, Piotr
Stawicki, Jakub
Komorzycka, Julia
Nowak, Karol
Tylutka, Anna
Zembron-Lacny, Agnieszka
author_sort Jarmuzek, Pawel
collection PubMed
description In some malignant tumours, the changes in neutrophil counts in relation to other blood cells are connected with unfavourable prognosis. Nevertheless, the prognostic value of the combinations of the haematological components in glioblastoma (GBM) remains under dispute. The clinical significance of the neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) was investigated in our study. We retrospectively studied 358 patients (males n = 195; females n = 163) aged 59.9 ± 13.5 yrs with newly diagnosed glioma and admitted to the Neurosurgery Centre. Routine blood tests and clinical characteristics were recorded within the first hour of hospital admission. The inflammatory variables: NLR, SII and SIRI exceeded the reference values and were significantly elevated in Grade 3 and Grade 4 tumour. The Cox model analysis showed that the age ≥ 63 years, NLR ≥ 4.56 × 10(3)/µL, SII ≥ 2003 × 10(3)/µL and SIRI ≥ 3.03 × 10(3)/µL significantly increased the risk of death in Grade 4 tumour patients. In the inflammatory variables, NLR demonstrated the highest impact on the survival time (HR 1.56; 95% CI 1.145–2.127; p = 0.005). In the first Polish study including GBM patients, the age in relation to simple parameters derived from complete blood cell count were found to have prognostic implications in the survival rate.
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spelling pubmed-92256362022-06-24 Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study Jarmuzek, Pawel Kot, Marcin Defort, Piotr Stawicki, Jakub Komorzycka, Julia Nowak, Karol Tylutka, Anna Zembron-Lacny, Agnieszka J Clin Med Article In some malignant tumours, the changes in neutrophil counts in relation to other blood cells are connected with unfavourable prognosis. Nevertheless, the prognostic value of the combinations of the haematological components in glioblastoma (GBM) remains under dispute. The clinical significance of the neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) was investigated in our study. We retrospectively studied 358 patients (males n = 195; females n = 163) aged 59.9 ± 13.5 yrs with newly diagnosed glioma and admitted to the Neurosurgery Centre. Routine blood tests and clinical characteristics were recorded within the first hour of hospital admission. The inflammatory variables: NLR, SII and SIRI exceeded the reference values and were significantly elevated in Grade 3 and Grade 4 tumour. The Cox model analysis showed that the age ≥ 63 years, NLR ≥ 4.56 × 10(3)/µL, SII ≥ 2003 × 10(3)/µL and SIRI ≥ 3.03 × 10(3)/µL significantly increased the risk of death in Grade 4 tumour patients. In the inflammatory variables, NLR demonstrated the highest impact on the survival time (HR 1.56; 95% CI 1.145–2.127; p = 0.005). In the first Polish study including GBM patients, the age in relation to simple parameters derived from complete blood cell count were found to have prognostic implications in the survival rate. MDPI 2022-06-13 /pmc/articles/PMC9225636/ /pubmed/35743468 http://dx.doi.org/10.3390/jcm11123397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jarmuzek, Pawel
Kot, Marcin
Defort, Piotr
Stawicki, Jakub
Komorzycka, Julia
Nowak, Karol
Tylutka, Anna
Zembron-Lacny, Agnieszka
Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
title Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
title_full Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
title_fullStr Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
title_full_unstemmed Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
title_short Prognostic Values of Combined Ratios of White Blood Cells in Glioblastoma: A Retrospective Study
title_sort prognostic values of combined ratios of white blood cells in glioblastoma: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225636/
https://www.ncbi.nlm.nih.gov/pubmed/35743468
http://dx.doi.org/10.3390/jcm11123397
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