Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme to...

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Detalles Bibliográficos
Autores principales: El-Dershaby, Nada H., El-Hawash, Soad A., Kassab, Shaymaa E., Dabees, Hoda G., Abdel Moneim, Ahmed E., Abdel Wahab, Ibrahim A., Abd-Alhaseeb, Mohammad M., El-Miligy, Mostafa M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225712/
https://www.ncbi.nlm.nih.gov/pubmed/35707920
http://dx.doi.org/10.1080/14756366.2022.2086868

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