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Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease

Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in the Alzheimer’s disease (AD) pathology. A series of novel thieno[3,2-c]pyrazol-3-amine derivatives were designed and synthesised and evaluated as potential GSK-3β inhibitors by structure-guided drug rational de...

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Detalles Bibliográficos
Autores principales:	Yan, Ning, Shi, Xiao-Long, Tang, Long-Qian, Wang, De-Feng, Li, Xun, Liu, Chao, Liu, Zhao-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225722/ https://www.ncbi.nlm.nih.gov/pubmed/35698879 http://dx.doi.org/10.1080/14756366.2022.2086867

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