Genetic correlation between thyroid hormones and Parkinson’s disease

Parkinson’s disease (PD) was reported to be connected with thyroid diseases clinically, which might be a critical clew to immune pathogenesis of PD. However, there was no further research to study the pathogenesis correlation between PD and thyroid diseases. In this study, except for investigating t...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Jiyi, Zhao, Cheng, Liu, Ye, Xu, Congjie, Qin, Bin, Liang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Neuroimmunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226140/
https://www.ncbi.nlm.nih.gov/pubmed/35511827
http://dx.doi.org/10.1093/cei/uxac044
Descripción
Sumario:Parkinson’s disease (PD) was reported to be connected with thyroid diseases clinically, which might be a critical clew to immune pathogenesis of PD. However, there was no further research to study the pathogenesis correlation between PD and thyroid diseases. In this study, except for investigating the difference in thyroid hormone between PD and the control group, we explored genetic correlation between thyroid and PD. We tried to find their shared molecular pathway by analyzing the effect of PD risk genes on thyroid function. Interestingly, most of those 12 meaningful SNPs we found could affect PD and thyroid function through immune mechanism, which is consistent with our original conjecture and provides significant evidence for the immune pathogenesis of PD.

Ejemplares similares