HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring

The body plan of animals is laid out by an evolutionary-conserved HOX code which is colinearly transcribed after zygotic genome activation (ZGA). Here we report that SMCHD1, a chromatin-modifying enzyme needed for X-inactivation in mammals, is maternally required for timely HOX expression. Using zeb...

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Detalles Bibliográficos
Autores principales: Xue, Shifeng, Ly, Thanh Thao Nguyen, Vijayakar, Raunak S., Chen, Jingyi, Ng, Joel, Mathuru, Ajay S., Magdinier, Frederique, Reversade, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226161/
https://www.ncbi.nlm.nih.gov/pubmed/35739109
http://dx.doi.org/10.1038/s41467-022-31185-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226161/
https://www.ncbi.nlm.nih.gov/pubmed/35739109
http://dx.doi.org/10.1038/s41467-022-31185-8

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