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Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

Mitochondrial ADP/ATP carriers import ADP into the mitochondrial matrix and export ATP to the cytosol to fuel cellular processes. Structures of the inhibited cytoplasmic- and matrix-open states have confirmed an alternating access transport mechanism, but the molecular details of substrate binding r...

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Detalles Bibliográficos
Autores principales:	Mavridou, Vasiliki, King, Martin S., Tavoulari, Sotiria, Ruprecht, Jonathan J., Palmer, Shane M., Kunji, Edmund R. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226169/ https://www.ncbi.nlm.nih.gov/pubmed/35739110 http://dx.doi.org/10.1038/s41467-022-31366-5

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