Probing TDP-43 condensation using an in silico designed aptamer

Aptamers are artificial oligonucleotides binding to specific molecular targets. They have a promising role in therapeutics and diagnostics but are often difficult to design. Here, we exploited the catRAPID algorithm to generate aptamers targeting TAR DNA-binding protein 43 (TDP-43), whose aggregatio...

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Detalles Bibliográficos
Autores principales: Zacco, Elsa, Kantelberg, Owen, Milanetti, Edoardo, Armaos, Alexandros, Panei, Francesco Paolo, Gregory, Jenna, Jeacock, Kiani, Clarke, David J., Chandran, Siddharthan, Ruocco, Giancarlo, Gustincich, Stefano, Horrocks, Mathew H., Pastore, Annalisa, Tartaglia, Gian Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226187/
https://www.ncbi.nlm.nih.gov/pubmed/35739092
http://dx.doi.org/10.1038/s41467-022-30944-x

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