Chk1 Inhibition Ameliorates Alzheimer’s Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling

Alzheimer’s disease (AD) is the most common neurodegenerative disease with limited therapeutic strategies. Cell cycle checkpoint protein kinase 1 (Chk1) is a Ser/Thr protein kinase which is activated in response to DNA damage, the latter which is an early event in AD. However, whether DNA damage-ind...

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Detalles Bibliográficos
Autores principales: Hu, Wenting, Wang, Zhuoqun, Zhang, Huiliang, Mahaman, Yacoubou Abdoul Razak, Huang, Fang, Meng, Dongli, Zhou, Ying, Wang, Shiyi, Jiang, Nan, Xiong, Jing, Westermarck, Jukka, Lu, Youming, Wang, Jianzhi, Wang, Xiaochuan, Shentu, Yangping, Liu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226264/
https://www.ncbi.nlm.nih.gov/pubmed/35286657
http://dx.doi.org/10.1007/s13311-022-01204-z

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