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Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice
Live attenuated vaccines often have beneficial non-specific effects, protecting against heterologous infectious and non-infectious diseases. We have developed a live attenuated pertussis vaccine, named BPZE1, currently in advanced clinical development. Here, we examined the prophylactic and therapeu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226346/ https://www.ncbi.nlm.nih.gov/pubmed/35739108 http://dx.doi.org/10.1038/s41541-022-00494-w |
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author | Belcher, Thomas Ait-Yahia, Saliha Solans, Luis Debrie, Anne-Sophie Cauchi, Stephane Tsicopoulos, Anne Locht, Camille |
author_facet | Belcher, Thomas Ait-Yahia, Saliha Solans, Luis Debrie, Anne-Sophie Cauchi, Stephane Tsicopoulos, Anne Locht, Camille |
author_sort | Belcher, Thomas |
collection | PubMed |
description | Live attenuated vaccines often have beneficial non-specific effects, protecting against heterologous infectious and non-infectious diseases. We have developed a live attenuated pertussis vaccine, named BPZE1, currently in advanced clinical development. Here, we examined the prophylactic and therapeutic potential of its pertactin-deficient derivative BPZE1P in a mouse model of house dust mite (HDM)-induced allergic airway inflammation (AAI). BPZE1P was given nasally either before or after sensitization with HDM, followed by HDM challenge, or between two challenge episodes. Vaccination prior to sensitization reduced resistance in the airways, the numbers of infiltrating eosinophils and the concentrations of proinflammatory cytokines, such as IL-1α, IL-1β and IL-33, in the lungs but had no effect on Th2 cytokine levels. BPZE1P also protected when delivered after sensitization or between two challenge episodes. However, in this case the levels of Th2 cytokines in the lung were decreased without significant effects on IL-1α, IL-1β and IL-33 production. The vaccine restored lung function and decreased eosinophil influx in the lungs of HDM-treated mice. BPZE1P has a better take than BPZE1 in hosts vaccinated with acellular pertussis vaccines. Therefore, it has interesting potential as a preventive and therapeutic agent against AAI, even in acellular pertussis-vaccinated populations. |
format | Online Article Text |
id | pubmed-9226346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92263462022-06-25 Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice Belcher, Thomas Ait-Yahia, Saliha Solans, Luis Debrie, Anne-Sophie Cauchi, Stephane Tsicopoulos, Anne Locht, Camille NPJ Vaccines Article Live attenuated vaccines often have beneficial non-specific effects, protecting against heterologous infectious and non-infectious diseases. We have developed a live attenuated pertussis vaccine, named BPZE1, currently in advanced clinical development. Here, we examined the prophylactic and therapeutic potential of its pertactin-deficient derivative BPZE1P in a mouse model of house dust mite (HDM)-induced allergic airway inflammation (AAI). BPZE1P was given nasally either before or after sensitization with HDM, followed by HDM challenge, or between two challenge episodes. Vaccination prior to sensitization reduced resistance in the airways, the numbers of infiltrating eosinophils and the concentrations of proinflammatory cytokines, such as IL-1α, IL-1β and IL-33, in the lungs but had no effect on Th2 cytokine levels. BPZE1P also protected when delivered after sensitization or between two challenge episodes. However, in this case the levels of Th2 cytokines in the lung were decreased without significant effects on IL-1α, IL-1β and IL-33 production. The vaccine restored lung function and decreased eosinophil influx in the lungs of HDM-treated mice. BPZE1P has a better take than BPZE1 in hosts vaccinated with acellular pertussis vaccines. Therefore, it has interesting potential as a preventive and therapeutic agent against AAI, even in acellular pertussis-vaccinated populations. Nature Publishing Group UK 2022-06-23 /pmc/articles/PMC9226346/ /pubmed/35739108 http://dx.doi.org/10.1038/s41541-022-00494-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Belcher, Thomas Ait-Yahia, Saliha Solans, Luis Debrie, Anne-Sophie Cauchi, Stephane Tsicopoulos, Anne Locht, Camille Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
title | Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
title_full | Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
title_fullStr | Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
title_full_unstemmed | Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
title_short | Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
title_sort | live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226346/ https://www.ncbi.nlm.nih.gov/pubmed/35739108 http://dx.doi.org/10.1038/s41541-022-00494-w |
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