Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications

The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to I...

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Autores principales: Internò, Valeria, Triggiano, Giacomo, De Santis, Pierluigi, Stucci, Luigia Stefania, Tucci, Marco, Porta, Camillo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226400/
https://www.ncbi.nlm.nih.gov/pubmed/35756624
http://dx.doi.org/10.3389/fonc.2022.866623
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author Internò, Valeria
Triggiano, Giacomo
De Santis, Pierluigi
Stucci, Luigia Stefania
Tucci, Marco
Porta, Camillo
author_facet Internò, Valeria
Triggiano, Giacomo
De Santis, Pierluigi
Stucci, Luigia Stefania
Tucci, Marco
Porta, Camillo
author_sort Internò, Valeria
collection PubMed
description The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. Moreover, the IDH-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (EGFR-amp) and mutation of the promoter of telomerase reverse transcriptase (pTERT-mut). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG.
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spelling pubmed-92264002022-06-25 Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications Internò, Valeria Triggiano, Giacomo De Santis, Pierluigi Stucci, Luigia Stefania Tucci, Marco Porta, Camillo Front Oncol Oncology The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. Moreover, the IDH-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (EGFR-amp) and mutation of the promoter of telomerase reverse transcriptase (pTERT-mut). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9226400/ /pubmed/35756624 http://dx.doi.org/10.3389/fonc.2022.866623 Text en Copyright © 2022 Internò, Triggiano, De Santis, Stucci, Tucci and Porta https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Internò, Valeria
Triggiano, Giacomo
De Santis, Pierluigi
Stucci, Luigia Stefania
Tucci, Marco
Porta, Camillo
Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
title Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
title_full Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
title_fullStr Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
title_full_unstemmed Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
title_short Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications
title_sort molecular aberrations stratify grade 2 astrocytomas into several rare entities: prognostic and therapeutic implications
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226400/
https://www.ncbi.nlm.nih.gov/pubmed/35756624
http://dx.doi.org/10.3389/fonc.2022.866623
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