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Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia
Although the biological relationship between vitamin D (VD) deficiency and cognitive function has been recognized by many scholars, the theoretical mechanisms involved are still not well-understood. In this study, we demonstrated the role of VD in alleviating the cognitive dysfunction in aged mice c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226433/ https://www.ncbi.nlm.nih.gov/pubmed/35754958 http://dx.doi.org/10.3389/fnagi.2022.940106 |
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author | Zhang, Jialei Zhang, Xiaoling Yang, Yongyan Zhao, Jun Hu, Wenqing Yu, Yonghao |
author_facet | Zhang, Jialei Zhang, Xiaoling Yang, Yongyan Zhao, Jun Hu, Wenqing Yu, Yonghao |
author_sort | Zhang, Jialei |
collection | PubMed |
description | Although the biological relationship between vitamin D (VD) deficiency and cognitive function has been recognized by many scholars, the theoretical mechanisms involved are still not well-understood. In this study, we demonstrated the role of VD in alleviating the cognitive dysfunction in aged mice caused by sevoflurane anesthesia. Forty female C57BL/6 mice aged 12 months were selected for the experiment. VD (-) and VD (+) mouse models and sevoflurane anesthesia models were established. Mice were randomly divided into normal elderly group (NC group), normal aged mice + sevoflurane anesthesia treatment group (NS group), aged VD (-) mice + sevoflurane anesthesia treatment group [VD (-) group], and aged VD (+) + sevoflurane anesthesia treatment group [VD (+) group]. To compare the emergence time after sevoflurane anesthesia in aged mice with different levels of VD and to test the cognitive function of four groups through the water maze. Inflammatory factor expression and cholinergic activity in hippocampus tissue of all mice were measured at the end of behavioral tests. These data show that, low levels of VD aggravated the delayed emergence and cognitive dysfunction in aged mice caused by sevoflurane anesthesia, while higher levels of VD mitigated this impairment by enhancing cholinergic activity and reducing inflammatory factor expression in the hippocampus. |
format | Online Article Text |
id | pubmed-9226433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92264332022-06-25 Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia Zhang, Jialei Zhang, Xiaoling Yang, Yongyan Zhao, Jun Hu, Wenqing Yu, Yonghao Front Aging Neurosci Neuroscience Although the biological relationship between vitamin D (VD) deficiency and cognitive function has been recognized by many scholars, the theoretical mechanisms involved are still not well-understood. In this study, we demonstrated the role of VD in alleviating the cognitive dysfunction in aged mice caused by sevoflurane anesthesia. Forty female C57BL/6 mice aged 12 months were selected for the experiment. VD (-) and VD (+) mouse models and sevoflurane anesthesia models were established. Mice were randomly divided into normal elderly group (NC group), normal aged mice + sevoflurane anesthesia treatment group (NS group), aged VD (-) mice + sevoflurane anesthesia treatment group [VD (-) group], and aged VD (+) + sevoflurane anesthesia treatment group [VD (+) group]. To compare the emergence time after sevoflurane anesthesia in aged mice with different levels of VD and to test the cognitive function of four groups through the water maze. Inflammatory factor expression and cholinergic activity in hippocampus tissue of all mice were measured at the end of behavioral tests. These data show that, low levels of VD aggravated the delayed emergence and cognitive dysfunction in aged mice caused by sevoflurane anesthesia, while higher levels of VD mitigated this impairment by enhancing cholinergic activity and reducing inflammatory factor expression in the hippocampus. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9226433/ /pubmed/35754958 http://dx.doi.org/10.3389/fnagi.2022.940106 Text en Copyright © 2022 Zhang, Zhang, Yang, Zhao, Hu and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Jialei Zhang, Xiaoling Yang, Yongyan Zhao, Jun Hu, Wenqing Yu, Yonghao Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia |
title | Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia |
title_full | Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia |
title_fullStr | Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia |
title_full_unstemmed | Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia |
title_short | Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia |
title_sort | effect of different vitamin d levels on cognitive function in aged mice after sevoflurane anesthesia |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226433/ https://www.ncbi.nlm.nih.gov/pubmed/35754958 http://dx.doi.org/10.3389/fnagi.2022.940106 |
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