Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli

Antisense peptide nucleic acids (PNAs) that target mRNAs of essential bacterial genes exhibit specific bactericidal effects in several microbial species, but our mechanistic understanding of PNA activity and their target gene spectrum is limited. Here, we present a systematic analysis of PNAs target...

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Detalles Bibliográficos
Autores principales: Popella, Linda, Jung, Jakob, Do, Phuong Thao, Hayward, Regan J, Barquist, Lars, Vogel, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226493/
https://www.ncbi.nlm.nih.gov/pubmed/35687096
http://dx.doi.org/10.1093/nar/gkac362

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