KDM6B promotes PARthanatos via suppression of O(6)-methylguanine DNA methyltransferase repair and sustained checkpoint response

Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA damage sensor and contributes to both DNA repair and cell death processes. However, how PARP-1 signaling is regulated to switch its function from DNA repair to cell death remains largely unknown. Here, we found that PARP-1 plays a central role in alkyl...

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Detalles Bibliográficos
Autores principales: Yang, Mingming, Wang, Chenliang, Zhou, Mi, Bao, Lei, Wang, Yanan, Kumar, Ashwani, Xing, Chao, Luo, Weibo, Wang, Yingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226499/
https://www.ncbi.nlm.nih.gov/pubmed/35648484
http://dx.doi.org/10.1093/nar/gkac471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226499/
https://www.ncbi.nlm.nih.gov/pubmed/35648484
http://dx.doi.org/10.1093/nar/gkac471

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