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MutL binds to 3′ resected DNA ends and blocks DNA polymerase access

DNA mismatch repair removes mis-incorporated bases after DNA replication and reduces the error rate a 100–1000-fold. After recognition of a mismatch, a large section of up to a thousand nucleotides is removed from the daughter strand followed by re-synthesis. How these opposite activities are coordi...

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Detalles Bibliográficos
Autores principales:	Borsellini, Alessandro, Lebbink, Joyce H G, Lamers, Meindert H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226502/ https://www.ncbi.nlm.nih.gov/pubmed/35670670 http://dx.doi.org/10.1093/nar/gkac432

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