Noncanonical NF-κB factor p100/p52 regulates homologous recombination and modulates sensitivity to DNA-damaging therapy

Homologous recombination (HR) serves multiple roles in DNA repair that are essential for maintaining genomic stability, including double-strand DNA break (DSB) repair. The central HR protein, RAD51, is frequently overexpressed in human malignancies, thereby elevating HR proficiency and promoting res...

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Detalles Bibliográficos
Autores principales: Budke, Brian, Zhong, Alison, Sullivan, Katherine, Park, Chanyoung, Gittin, David I, Kountz, Timothy S, Connell, Philip P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226503/
https://www.ncbi.nlm.nih.gov/pubmed/35689636
http://dx.doi.org/10.1093/nar/gkac491

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