TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers

Chromosome 17q23 amplification occurs in 20% of primary breast tumours and is associated with poor outcome. The TBX2 gene is located on 17q23 and is often over-expressed in this breast tumour subset. TBX2 is an anti-senescence gene, promoting cell growth and survival through repression of Tumour Sup...

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Detalles Bibliográficos
Autores principales: McIntyre, Alexander J, Angel, Charlotte Z, Smith, James S, Templeman, Amy, Beattie, Katherine, Beattie, Shannon, Ormrod, Alice, Devlin, Eadaoin, McGreevy, Charles, Bothwell, Chloe, Eddie, Sharon L, Buckley, Niamh E, Williams, Rich, Mullan, Paul B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226508/
https://www.ncbi.nlm.nih.gov/pubmed/35687133
http://dx.doi.org/10.1093/nar/gkac494

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