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A pathway independent multi-modular ordered control system based on thermosensors and CRISPRi improves bioproduction in Bacillus subtilis

Dynamic regulation is an effective strategy for control of gene expression in microbial cell factories. In some pathway contexts, several metabolic modules must be controlled in a time dependent or ordered manner to maximize production, while the creation of genetic circuits with ordered regulation...

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Detalles Bibliográficos
Autores principales:	Yu, Wenwen, Jin, Ke, Wu, Yaokang, Zhang, Quanwei, Liu, Yanfeng, Li, Jianghua, Du, Guocheng, Chen, Jian, Lv, Xueqin, Ledesma-Amaro, Rodrigo, Liu, Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226513/ https://www.ncbi.nlm.nih.gov/pubmed/35670665 http://dx.doi.org/10.1093/nar/gkac476

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