Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery

Schlafen-5 (SLFN5) is an interferon-induced protein of the Schlafen family, which are involved in immune responses and oncogenesis. To date, little is known regarding its anti-HIV-1 function. Here, the authors report that overexpression of SLFN5 inhibits HIV-1 replication and reduces viral mRNA leve...

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Detalles Bibliográficos
Autores principales: Ding, Jiwei, Wang, Shujie, Wang, Zhen, Chen, Shumin, Zhao, Jianyuan, Solomon, Magan, Liu, Zhenlong, Guo, Fei, Ma, Ling, Wen, Jiajia, Li, Xiaoyu, Liang, Chen, Cen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226525/
https://www.ncbi.nlm.nih.gov/pubmed/35687115
http://dx.doi.org/10.1093/nar/gkac489

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