Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells

Prime editors consisting of Cas9-nickase and reverse transcriptase enable targeted precise editing of small DNA pieces, including all 12 kinds of base substitutions, insertions and deletions, while without requiring double-strand breaks or donor templates. Current optimized prime editing strategy (P...

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Detalles Bibliográficos
Autores principales: Tao, Rui, Wang, Yanhong, Jiao, Yaoge, Hu, Yun, Li, Li, Jiang, Lurong, Zhou, Lifang, Qu, Junyan, Chen, Qiang, Yao, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226529/
https://www.ncbi.nlm.nih.gov/pubmed/35687127
http://dx.doi.org/10.1093/nar/gkac506

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