The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects

Translation initiation in eukaryotes starts with the recognition of the mRNA 5′-cap by eIF4F, a hetero-trimeric complex of eIF4E, the cap-binding protein, eIF4A, a DEAD-box helicase, and eIF4G, a scaffold protein. eIF4G comprises eIF4E- and eIF4A-binding domains (4E-BD, 4A-BD) and three RNA-binding...

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Detalles Bibliográficos
Autores principales: Krause, Linda, Willing, Florian, Andreou, Alexandra Zoi, Klostermeier, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226541/
https://www.ncbi.nlm.nih.gov/pubmed/35689631
http://dx.doi.org/10.1093/nar/gkac437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226541/
https://www.ncbi.nlm.nih.gov/pubmed/35689631
http://dx.doi.org/10.1093/nar/gkac437

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