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Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages
Metabolic disorders (i.e., hyperglycemia, hyperlipidemia, and hyperinsulinemia) cause increased secretion of inflammatory cytokines/chemokines, leading to gradual loss of cardiac resident macrophage population and increased accumulation of inflammatory monocytes/macrophages in the heart. Such self-p...
Autores principales: | Li, Qianqian, Li, Yutian, Huang, Wei, Wang, Xiaohong, Liu, Zhenling, Chen, Jing, Fan, Yanbo, Peng, Tianqing, Sadayappan, Sakthivel, Wang, Yigang, Fan, Guo-Chang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226549/ https://www.ncbi.nlm.nih.gov/pubmed/35757735 http://dx.doi.org/10.3389/fimmu.2022.930397 |
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