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Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome

In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS. Previously, we showed that the formulation of methotrexate (MTX) associated with lipid nanoparticles (LDE)...

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Detalles Bibliográficos
Autores principales:	Guido, Maria Carolina, Lopes, Natalia de Menezes, Albuquerque, Camila Inagaki, Tavares, Elaine Rufo, Jensen, Leonardo, Carvalho, Priscila de Oliveira, Tavoni, Thauany Martins, Dias, Ricardo Ribeiro, Pereira, Lygia da Veiga, Laurindo, Francisco Rafael Martins, Maranhão, Raul Cavalcante
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226570/ https://www.ncbi.nlm.nih.gov/pubmed/35757348 http://dx.doi.org/10.3389/fcvm.2022.893774

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