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False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators
Real-time reverse transcription-polymerase chain reaction (RT-PCR) is the gold standard for diagnosing coronavirus disease 2019 (COVID-19). However, RT-PCR may yield false-positive results, leading to unnecessary countermeasures. Here, we report a “positive” nucleic acid test on a 10-pooled sample d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226675/ https://www.ncbi.nlm.nih.gov/pubmed/35755058 http://dx.doi.org/10.3389/fmed.2022.847407 |
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author | Kong, Xiang-Qi Wang, Yong-Jing Fang, Zan-Xi Yang, Tian-Ci Tong, Man-Li |
author_facet | Kong, Xiang-Qi Wang, Yong-Jing Fang, Zan-Xi Yang, Tian-Ci Tong, Man-Li |
author_sort | Kong, Xiang-Qi |
collection | PubMed |
description | Real-time reverse transcription-polymerase chain reaction (RT-PCR) is the gold standard for diagnosing coronavirus disease 2019 (COVID-19). However, RT-PCR may yield false-positive results, leading to unnecessary countermeasures. Here, we report a “positive” nucleic acid test on a 10-pooled sample during the routine screening that caused many adverse societal effects, and financial and resource losses. However, they were subsequently determined to be a case of vaccine contamination. This case study increases awareness of false-positive RT-PCR results for SARS-CoV-2, especially when participants are vaccinators. Moreover, it could provide relevant suggestions to prevent the recurrence of such incidents. |
format | Online Article Text |
id | pubmed-9226675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92266752022-06-25 False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators Kong, Xiang-Qi Wang, Yong-Jing Fang, Zan-Xi Yang, Tian-Ci Tong, Man-Li Front Med (Lausanne) Medicine Real-time reverse transcription-polymerase chain reaction (RT-PCR) is the gold standard for diagnosing coronavirus disease 2019 (COVID-19). However, RT-PCR may yield false-positive results, leading to unnecessary countermeasures. Here, we report a “positive” nucleic acid test on a 10-pooled sample during the routine screening that caused many adverse societal effects, and financial and resource losses. However, they were subsequently determined to be a case of vaccine contamination. This case study increases awareness of false-positive RT-PCR results for SARS-CoV-2, especially when participants are vaccinators. Moreover, it could provide relevant suggestions to prevent the recurrence of such incidents. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9226675/ /pubmed/35755058 http://dx.doi.org/10.3389/fmed.2022.847407 Text en Copyright © 2022 Kong, Wang, Fang, Yang and Tong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Kong, Xiang-Qi Wang, Yong-Jing Fang, Zan-Xi Yang, Tian-Ci Tong, Man-Li False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators |
title | False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators |
title_full | False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators |
title_fullStr | False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators |
title_full_unstemmed | False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators |
title_short | False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators |
title_sort | false-positive results of sars-cov-2 rt-pcr in oropharyngeal swabs from vaccinators |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226675/ https://www.ncbi.nlm.nih.gov/pubmed/35755058 http://dx.doi.org/10.3389/fmed.2022.847407 |
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