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Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity

OBJECTIVE: To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 [TGF-β1]), and cardiometabolic and anthropometric measures in males with obesit...

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Autores principales: Ataeinosrat, Ali, Saeidi, Ayoub, Abednatanzi, Hossein, Rahmani, Hiwa, Daloii, Asieh Abbassi, Pashaei, Zhaleh, Hojati, Vida, Basati, Gholam, Mossayebi, Ali, Laher, Ismail, Alesi, Michaela G., Hackney, Anthony C., VanDusseldorp, Trisha A., Zouhal, Hassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226680/
https://www.ncbi.nlm.nih.gov/pubmed/35757424
http://dx.doi.org/10.3389/fendo.2022.895512
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author Ataeinosrat, Ali
Saeidi, Ayoub
Abednatanzi, Hossein
Rahmani, Hiwa
Daloii, Asieh Abbassi
Pashaei, Zhaleh
Hojati, Vida
Basati, Gholam
Mossayebi, Ali
Laher, Ismail
Alesi, Michaela G.
Hackney, Anthony C.
VanDusseldorp, Trisha A.
Zouhal, Hassane
author_facet Ataeinosrat, Ali
Saeidi, Ayoub
Abednatanzi, Hossein
Rahmani, Hiwa
Daloii, Asieh Abbassi
Pashaei, Zhaleh
Hojati, Vida
Basati, Gholam
Mossayebi, Ali
Laher, Ismail
Alesi, Michaela G.
Hackney, Anthony C.
VanDusseldorp, Trisha A.
Zouhal, Hassane
author_sort Ataeinosrat, Ali
collection PubMed
description OBJECTIVE: To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 [TGF-β1]), and cardiometabolic and anthropometric measures in males with obesity. METHODS: Forty-four obese males (age: 27.5 ± 9.4 yr.; height: 165.4 ± 2.8 cm; weight: 97.9 ± 2.6 kg and BMI: 35.7 ± 4.3 kg/m(2)) were randomly assigned to one of four groups (n=11 per group): low-intensity interval resistance training (LIIRT), moderate-intensity interval resistance training (MIIRT), high-intensity interval resistance training (HIIRT) or control (C). The LIIRT group performed 10 exercises in 3 sets of 40% (20 repetitions), the MIIRT group performed 10 exercises in three sets of 60% (13 repetitions), and the HIIRT group performed 10 exercises in three sets of 80% (10 repetitions) of one maximum repetition (1RM), which were followed with active rest of 20% of 1RM and 15 repetitions. The resistance training groups exercised ~70 min per session, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training. RESULTS: Baseline levels of myokines, cardiovascular risk factors, anthropometry, body composition, and cardio-respiratory fitness were not different between the four groups (p>0.05). The group x time interactions for decorin, activin A, follistatin, myostatin, and TGF-β1, total cholesterol (TC), triglyceride (TG), high-density cholesterol (HDL), low-density cholesterol (LDL), anthropometry, body composition, and cardio-respiratory fitness were statistically significant (p<0.05). There were increases in post-test values for decorin, follistatin, HDL (p<0.05) and decreases in TC, TG, TGF-β1, LDL, and myostatin levels in the LIIRT, MIIRT, and HIIRT groups compared to pretest values (p<0.05). Changes in fat mass, VO(2peak,) HDL, TG, glucose, activin A, decorin were not significant in LIIRT compared to the control group, while changes in activin A, follistatin, and TFG-β1 levels were greater in HIIRT and MIIRT groups compared to the LIIRT group (p<0.05). CONCLUSION: The LIIRT, MIIRT, and HIIRT protocols all produced beneficial changes in decorin, activin A, follistatin, myostatin, and TGF-β1 levels, and cardiometabolic risk factors, with greater effects from the MIIRT and HIIRT protocols compared to LIIRT.
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spelling pubmed-92266802022-06-25 Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity Ataeinosrat, Ali Saeidi, Ayoub Abednatanzi, Hossein Rahmani, Hiwa Daloii, Asieh Abbassi Pashaei, Zhaleh Hojati, Vida Basati, Gholam Mossayebi, Ali Laher, Ismail Alesi, Michaela G. Hackney, Anthony C. VanDusseldorp, Trisha A. Zouhal, Hassane Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: To determine the effects of different intensities of interval resistance training (IRT) protocols on the levels of select myokines (decorin, follistatin, myostatin, activin A, transforming growth factor beta-1 [TGF-β1]), and cardiometabolic and anthropometric measures in males with obesity. METHODS: Forty-four obese males (age: 27.5 ± 9.4 yr.; height: 165.4 ± 2.8 cm; weight: 97.9 ± 2.6 kg and BMI: 35.7 ± 4.3 kg/m(2)) were randomly assigned to one of four groups (n=11 per group): low-intensity interval resistance training (LIIRT), moderate-intensity interval resistance training (MIIRT), high-intensity interval resistance training (HIIRT) or control (C). The LIIRT group performed 10 exercises in 3 sets of 40% (20 repetitions), the MIIRT group performed 10 exercises in three sets of 60% (13 repetitions), and the HIIRT group performed 10 exercises in three sets of 80% (10 repetitions) of one maximum repetition (1RM), which were followed with active rest of 20% of 1RM and 15 repetitions. The resistance training groups exercised ~70 min per session, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training. RESULTS: Baseline levels of myokines, cardiovascular risk factors, anthropometry, body composition, and cardio-respiratory fitness were not different between the four groups (p>0.05). The group x time interactions for decorin, activin A, follistatin, myostatin, and TGF-β1, total cholesterol (TC), triglyceride (TG), high-density cholesterol (HDL), low-density cholesterol (LDL), anthropometry, body composition, and cardio-respiratory fitness were statistically significant (p<0.05). There were increases in post-test values for decorin, follistatin, HDL (p<0.05) and decreases in TC, TG, TGF-β1, LDL, and myostatin levels in the LIIRT, MIIRT, and HIIRT groups compared to pretest values (p<0.05). Changes in fat mass, VO(2peak,) HDL, TG, glucose, activin A, decorin were not significant in LIIRT compared to the control group, while changes in activin A, follistatin, and TFG-β1 levels were greater in HIIRT and MIIRT groups compared to the LIIRT group (p<0.05). CONCLUSION: The LIIRT, MIIRT, and HIIRT protocols all produced beneficial changes in decorin, activin A, follistatin, myostatin, and TGF-β1 levels, and cardiometabolic risk factors, with greater effects from the MIIRT and HIIRT protocols compared to LIIRT. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9226680/ /pubmed/35757424 http://dx.doi.org/10.3389/fendo.2022.895512 Text en Copyright © 2022 Ataeinosrat, Saeidi, Abednatanzi, Rahmani, Daloii, Pashaei, Hojati, Basati, Mossayebi, Laher, Alesi, Hackney, VanDusseldorp and Zouhal https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ataeinosrat, Ali
Saeidi, Ayoub
Abednatanzi, Hossein
Rahmani, Hiwa
Daloii, Asieh Abbassi
Pashaei, Zhaleh
Hojati, Vida
Basati, Gholam
Mossayebi, Ali
Laher, Ismail
Alesi, Michaela G.
Hackney, Anthony C.
VanDusseldorp, Trisha A.
Zouhal, Hassane
Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
title Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
title_full Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
title_fullStr Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
title_full_unstemmed Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
title_short Intensity Dependent Effects of Interval Resistance Training on Myokines and Cardiovascular Risk Factors in Males With Obesity
title_sort intensity dependent effects of interval resistance training on myokines and cardiovascular risk factors in males with obesity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226680/
https://www.ncbi.nlm.nih.gov/pubmed/35757424
http://dx.doi.org/10.3389/fendo.2022.895512
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