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Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults

OBJECTIVE: This study examined the association of lifetime experiences, measured by a cognitive reserve (CR) composite score composed of years of education, literacy, and vocabulary measures, to level and rate of change in white matter microstructure, as assessed by diffusion tensor imaging (DTI) me...

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Autores principales: Brichko, Rostislav, Soldan, Anja, Zhu, Yuxin, Wang, Mei-Cheng, Faria, Andreia, Albert, Marilyn, Pettigrew, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226781/
https://www.ncbi.nlm.nih.gov/pubmed/35756247
http://dx.doi.org/10.3389/fpsyg.2022.859826
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author Brichko, Rostislav
Soldan, Anja
Zhu, Yuxin
Wang, Mei-Cheng
Faria, Andreia
Albert, Marilyn
Pettigrew, Corinne
author_facet Brichko, Rostislav
Soldan, Anja
Zhu, Yuxin
Wang, Mei-Cheng
Faria, Andreia
Albert, Marilyn
Pettigrew, Corinne
author_sort Brichko, Rostislav
collection PubMed
description OBJECTIVE: This study examined the association of lifetime experiences, measured by a cognitive reserve (CR) composite score composed of years of education, literacy, and vocabulary measures, to level and rate of change in white matter microstructure, as assessed by diffusion tensor imaging (DTI) measures. We also examined whether the relationship between the proxy CR composite score and white matter microstructure was modified by participant age, APOE-ε4 genetic status, and level of vascular risk. METHODS: A sample of 192 non-demented (n = 166 cognitively normal, n = 26 mild cognitive impairment) older adults [mean age = 70.17 (SD = 8.5) years] from the BIOCARD study underwent longitudinal DTI (mean follow-up = 2.5 years, max = 4.7 years). White matter microstructure was quantified by fractional anisotropy (FA) and radial diffusivity (RD) values in global white matter tracts and medial temporal lobe (MTL) white matter tracts. RESULTS: Using longitudinal linear mixed effect models, we found that FA decreased over time and RD increased over time in both the global and MTL DTI composites, but the rate of change in these DTI measures was not related to level of CR. However, there were significant interactions between the CR composite score and age for global RD in the full sample, and for global FA, global RD, and MTL RD among those with normal cognition. These interactions indicated that among participants with a lower baseline age, higher CR composite scores were associated with higher FA and lower RD values, while among participants with higher age at baseline, higher CR composite scores were associated with lower FA and higher RD values. Furthermore, these relationships were not modified by APOE-ε4 genotype or level of vascular risk. CONCLUSION: The association between level of CR and DTI measures differs by age, suggesting a possible neuroprotective effect of CR among late middle-aged adults that shifts to a compensatory effect among older adults.
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spelling pubmed-92267812022-06-25 Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults Brichko, Rostislav Soldan, Anja Zhu, Yuxin Wang, Mei-Cheng Faria, Andreia Albert, Marilyn Pettigrew, Corinne Front Psychol Psychology OBJECTIVE: This study examined the association of lifetime experiences, measured by a cognitive reserve (CR) composite score composed of years of education, literacy, and vocabulary measures, to level and rate of change in white matter microstructure, as assessed by diffusion tensor imaging (DTI) measures. We also examined whether the relationship between the proxy CR composite score and white matter microstructure was modified by participant age, APOE-ε4 genetic status, and level of vascular risk. METHODS: A sample of 192 non-demented (n = 166 cognitively normal, n = 26 mild cognitive impairment) older adults [mean age = 70.17 (SD = 8.5) years] from the BIOCARD study underwent longitudinal DTI (mean follow-up = 2.5 years, max = 4.7 years). White matter microstructure was quantified by fractional anisotropy (FA) and radial diffusivity (RD) values in global white matter tracts and medial temporal lobe (MTL) white matter tracts. RESULTS: Using longitudinal linear mixed effect models, we found that FA decreased over time and RD increased over time in both the global and MTL DTI composites, but the rate of change in these DTI measures was not related to level of CR. However, there were significant interactions between the CR composite score and age for global RD in the full sample, and for global FA, global RD, and MTL RD among those with normal cognition. These interactions indicated that among participants with a lower baseline age, higher CR composite scores were associated with higher FA and lower RD values, while among participants with higher age at baseline, higher CR composite scores were associated with lower FA and higher RD values. Furthermore, these relationships were not modified by APOE-ε4 genotype or level of vascular risk. CONCLUSION: The association between level of CR and DTI measures differs by age, suggesting a possible neuroprotective effect of CR among late middle-aged adults that shifts to a compensatory effect among older adults. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9226781/ /pubmed/35756247 http://dx.doi.org/10.3389/fpsyg.2022.859826 Text en Copyright © 2022 Brichko, Soldan, Zhu, Wang, Faria, Albert, Pettigrew and The BIOCARD Research Team. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Brichko, Rostislav
Soldan, Anja
Zhu, Yuxin
Wang, Mei-Cheng
Faria, Andreia
Albert, Marilyn
Pettigrew, Corinne
Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
title Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
title_full Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
title_fullStr Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
title_full_unstemmed Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
title_short Age-Dependent Association Between Cognitive Reserve Proxy and Longitudinal White Matter Microstructure in Older Adults
title_sort age-dependent association between cognitive reserve proxy and longitudinal white matter microstructure in older adults
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226781/
https://www.ncbi.nlm.nih.gov/pubmed/35756247
http://dx.doi.org/10.3389/fpsyg.2022.859826
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