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Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting

PURPOSE: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the effects of different asthma medications on exacerbation in a real-world setting. MATERIALS AND METHODS: We retrospectively reviewed electronic medical records of asthma patient...

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Autores principales: Choi, Yong Jun, Kim, Chang-Hwa, Lee, Jaeuk, Byun, Min Kwang, Cho, Jae Hwa, Park, Hye Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226836/
https://www.ncbi.nlm.nih.gov/pubmed/35748071
http://dx.doi.org/10.3349/ymj.2022.63.7.603
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author Choi, Yong Jun
Kim, Chang-Hwa
Lee, Jaeuk
Byun, Min Kwang
Cho, Jae Hwa
Park, Hye Jung
author_facet Choi, Yong Jun
Kim, Chang-Hwa
Lee, Jaeuk
Byun, Min Kwang
Cho, Jae Hwa
Park, Hye Jung
author_sort Choi, Yong Jun
collection PubMed
description PURPOSE: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the effects of different asthma medications on exacerbation in a real-world setting. MATERIALS AND METHODS: We retrospectively reviewed electronic medical records of asthma patients who visited the hospital from November 1, 2016 to October 31, 2019. The number of asthma exacerbations requiring administration of systemic steroids was the primary outcome. A time-varying Cox regression analysis was used to reflect the real-world setting: variable usage times, discontinuation, and switching of medication. RESULTS: Among 937 patients with asthma, 228 (24.3%) experienced asthma exacerbation during the study period. Asthma exacerbation was observed in patients using short-acting β(2)-agonists (SABA) alone (50.4% vs. 28.6%, p<0.001) as well as in patients not using inhaled corticosteroids (ICS) (58.8% vs. 40.3%, p<0.001), long-acting β(2)-agonists (LABA) (54.8% vs. 36.1%, p<0.001), and leukotriene receptor antagonists (71.5% vs. 50.8%, p<0.001). A time-varying Cox regression analysis of asthma exacerbations according to the duration of asthma medication showed that SABA alone increased the risk of asthma exacerbation [hazard ratio (HR), 1.834; 95% confidence interval (CI), 1.299–2.588; p=0.001], whereas ICS-LABA decreased the risk (HR, 0.733; 95% CI, 0.538–0.997; p=0.048). However, in the subgroup analysis according to medication type, specific ingredients showed no significant differences. CONCLUSION: In the real world, asthma medications affect asthma exacerbation variably according to the medication type.
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spelling pubmed-92268362022-07-07 Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting Choi, Yong Jun Kim, Chang-Hwa Lee, Jaeuk Byun, Min Kwang Cho, Jae Hwa Park, Hye Jung Yonsei Med J Original Article PURPOSE: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the effects of different asthma medications on exacerbation in a real-world setting. MATERIALS AND METHODS: We retrospectively reviewed electronic medical records of asthma patients who visited the hospital from November 1, 2016 to October 31, 2019. The number of asthma exacerbations requiring administration of systemic steroids was the primary outcome. A time-varying Cox regression analysis was used to reflect the real-world setting: variable usage times, discontinuation, and switching of medication. RESULTS: Among 937 patients with asthma, 228 (24.3%) experienced asthma exacerbation during the study period. Asthma exacerbation was observed in patients using short-acting β(2)-agonists (SABA) alone (50.4% vs. 28.6%, p<0.001) as well as in patients not using inhaled corticosteroids (ICS) (58.8% vs. 40.3%, p<0.001), long-acting β(2)-agonists (LABA) (54.8% vs. 36.1%, p<0.001), and leukotriene receptor antagonists (71.5% vs. 50.8%, p<0.001). A time-varying Cox regression analysis of asthma exacerbations according to the duration of asthma medication showed that SABA alone increased the risk of asthma exacerbation [hazard ratio (HR), 1.834; 95% confidence interval (CI), 1.299–2.588; p=0.001], whereas ICS-LABA decreased the risk (HR, 0.733; 95% CI, 0.538–0.997; p=0.048). However, in the subgroup analysis according to medication type, specific ingredients showed no significant differences. CONCLUSION: In the real world, asthma medications affect asthma exacerbation variably according to the medication type. Yonsei University College of Medicine 2022-07 2022-06-14 /pmc/articles/PMC9226836/ /pubmed/35748071 http://dx.doi.org/10.3349/ymj.2022.63.7.603 Text en © Copyright: Yonsei University College of Medicine 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Yong Jun
Kim, Chang-Hwa
Lee, Jaeuk
Byun, Min Kwang
Cho, Jae Hwa
Park, Hye Jung
Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting
title Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting
title_full Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting
title_fullStr Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting
title_full_unstemmed Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting
title_short Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting
title_sort effects of asthma medication type on asthma exacerbation in a real-world setting
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226836/
https://www.ncbi.nlm.nih.gov/pubmed/35748071
http://dx.doi.org/10.3349/ymj.2022.63.7.603
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