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Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis

BACKGROUND: Peak width of Skeletonized Mean Diffusivity (PSMD), as a novel marker of white matter (WM) microstructure damage, is associated with cognitive decline in several WM pathologies (i.e., small vessel disorders). We hypothesized that markers combining alterations in whole WM could be associa...

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Autores principales: Chylińska, Magdalena, Karaszewski, Bartosz, Komendziński, Jakub, Wyszomirski, Adam, Sabisz, Agnieszka, Halas, Marek, Szurowska, Edyta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226842/
https://www.ncbi.nlm.nih.gov/pubmed/35560868
http://dx.doi.org/10.1002/brb3.2591
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author Chylińska, Magdalena
Karaszewski, Bartosz
Komendziński, Jakub
Wyszomirski, Adam
Sabisz, Agnieszka
Halas, Marek
Szurowska, Edyta
author_facet Chylińska, Magdalena
Karaszewski, Bartosz
Komendziński, Jakub
Wyszomirski, Adam
Sabisz, Agnieszka
Halas, Marek
Szurowska, Edyta
author_sort Chylińska, Magdalena
collection PubMed
description BACKGROUND: Peak width of Skeletonized Mean Diffusivity (PSMD), as a novel marker of white matter (WM) microstructure damage, is associated with cognitive decline in several WM pathologies (i.e., small vessel disorders). We hypothesized that markers combining alterations in whole WM could be associated with cognitive dysfunction in relapsing‐remitting multiple sclerosis (RRMS) patients. METHODS: We used PSMD based on tract‐based spatial statistics (TBSS) of diffusion tensor imaging (DTI) magnetic resonance (MR) scans. We investigated RRMS patients (n = 73) undergoing interferon beta (IFN‐β) therapy. In this cross‐sectional study, we investigated the association between neuropsychological data and clinical and MRI variables: PSMD, WM hypointensities, and normalized brain volume (NBV). RESULTS: In our cohort, 37 (50.7%) patients were recognized as cognitively impaired (CI) and 36 (49.3%) patients were cognitively normal (CN). In regression analysis, PSMD was a statistically significant contributor in the California Verbal Learning Test (CVLT) list A (p = 0.04) and semantic fluency (p = 0.036). PSMD (p < 0.001, r (2 )= 0.35), NBV (p = 0.002, r (2 )= 2.6) and WM hypointensities (p < 0.001, r (2 )= 0.40) were major contributors to upper extremity disability (9HPT) in the CN subgroup. A significant contributor in the majority of neuropsychological measures was education attainment. CONCLUSION: We investigated PSMD as a new parameter of WM microstructure damage that is a contributor in complex cognitive tasks, CVLT performance, and semantic fluency. PSMD was a statistically significant contributor to upper extremity disability (9HPT) together with WM hypointensities and NBV. Education attainment proved to be relevant in the majority of cognitive domains. Further studies are needed to estimate PSMD relevance as a marker of CI in MS.
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spelling pubmed-92268422022-06-30 Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis Chylińska, Magdalena Karaszewski, Bartosz Komendziński, Jakub Wyszomirski, Adam Sabisz, Agnieszka Halas, Marek Szurowska, Edyta Brain Behav Original Articles BACKGROUND: Peak width of Skeletonized Mean Diffusivity (PSMD), as a novel marker of white matter (WM) microstructure damage, is associated with cognitive decline in several WM pathologies (i.e., small vessel disorders). We hypothesized that markers combining alterations in whole WM could be associated with cognitive dysfunction in relapsing‐remitting multiple sclerosis (RRMS) patients. METHODS: We used PSMD based on tract‐based spatial statistics (TBSS) of diffusion tensor imaging (DTI) magnetic resonance (MR) scans. We investigated RRMS patients (n = 73) undergoing interferon beta (IFN‐β) therapy. In this cross‐sectional study, we investigated the association between neuropsychological data and clinical and MRI variables: PSMD, WM hypointensities, and normalized brain volume (NBV). RESULTS: In our cohort, 37 (50.7%) patients were recognized as cognitively impaired (CI) and 36 (49.3%) patients were cognitively normal (CN). In regression analysis, PSMD was a statistically significant contributor in the California Verbal Learning Test (CVLT) list A (p = 0.04) and semantic fluency (p = 0.036). PSMD (p < 0.001, r (2 )= 0.35), NBV (p = 0.002, r (2 )= 2.6) and WM hypointensities (p < 0.001, r (2 )= 0.40) were major contributors to upper extremity disability (9HPT) in the CN subgroup. A significant contributor in the majority of neuropsychological measures was education attainment. CONCLUSION: We investigated PSMD as a new parameter of WM microstructure damage that is a contributor in complex cognitive tasks, CVLT performance, and semantic fluency. PSMD was a statistically significant contributor to upper extremity disability (9HPT) together with WM hypointensities and NBV. Education attainment proved to be relevant in the majority of cognitive domains. Further studies are needed to estimate PSMD relevance as a marker of CI in MS. John Wiley and Sons Inc. 2022-05-13 /pmc/articles/PMC9226842/ /pubmed/35560868 http://dx.doi.org/10.1002/brb3.2591 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Chylińska, Magdalena
Karaszewski, Bartosz
Komendziński, Jakub
Wyszomirski, Adam
Sabisz, Agnieszka
Halas, Marek
Szurowska, Edyta
Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
title Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
title_full Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
title_fullStr Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
title_full_unstemmed Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
title_short Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
title_sort skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226842/
https://www.ncbi.nlm.nih.gov/pubmed/35560868
http://dx.doi.org/10.1002/brb3.2591
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