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The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation
There is a need for alternatives to positive airway pressure for the treatment of obstructive sleep apnea and snoring. Improving upper airway dilator function might alleviate upper airway obstruction. We hypothesized that transoral neuromuscular stimulation would reduce upper airway collapse in conc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226850/ https://www.ncbi.nlm.nih.gov/pubmed/35748091 http://dx.doi.org/10.14814/phy2.15360 |
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author | Nokes, Brandon Schmickl, Christopher N. Brena, Rebbecca Bosompra, Nana Naa‐Oye Gilbertson, Dillon Sands, Scott A. Bhattacharjee, Rakesh Mann, Dwayne L. Owens, Robert L. Malhotra, Atul Orr, Jeremy E. |
author_facet | Nokes, Brandon Schmickl, Christopher N. Brena, Rebbecca Bosompra, Nana Naa‐Oye Gilbertson, Dillon Sands, Scott A. Bhattacharjee, Rakesh Mann, Dwayne L. Owens, Robert L. Malhotra, Atul Orr, Jeremy E. |
author_sort | Nokes, Brandon |
collection | PubMed |
description | There is a need for alternatives to positive airway pressure for the treatment of obstructive sleep apnea and snoring. Improving upper airway dilator function might alleviate upper airway obstruction. We hypothesized that transoral neuromuscular stimulation would reduce upper airway collapse in concert with improvement in genioglossal muscle function. Subjects with simple snoring and mild OSA (AHI < 15/h on screening) underwent in‐laboratory polysomnography with concurrent genioglossal electromyography (EMGgg) before and after 4–6 weeks of twice‐daily transoral neuromuscular stimulation. Twenty patients completed the study: Sixteen males, mean ± SD age 40 ± 13 years, and BMI 26.3 ± 3.8 kg/m(2). Although there was no change in non‐rapid eye movement EMGgg phasic (p = 0.66) or tonic activity (p = 0.83), and no decrease in snoring or flow limitation, treatment was associated with improvements in tongue endurance, sleep quality, and sleep efficiency. In this protocol, transoral neurostimulation did not result in changes in genioglossal activity or upper airway collapse, but other beneficial effects were noted suggesting a need for additional mechanistic investigation. |
format | Online Article Text |
id | pubmed-9226850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92268502022-06-30 The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation Nokes, Brandon Schmickl, Christopher N. Brena, Rebbecca Bosompra, Nana Naa‐Oye Gilbertson, Dillon Sands, Scott A. Bhattacharjee, Rakesh Mann, Dwayne L. Owens, Robert L. Malhotra, Atul Orr, Jeremy E. Physiol Rep Original Articles There is a need for alternatives to positive airway pressure for the treatment of obstructive sleep apnea and snoring. Improving upper airway dilator function might alleviate upper airway obstruction. We hypothesized that transoral neuromuscular stimulation would reduce upper airway collapse in concert with improvement in genioglossal muscle function. Subjects with simple snoring and mild OSA (AHI < 15/h on screening) underwent in‐laboratory polysomnography with concurrent genioglossal electromyography (EMGgg) before and after 4–6 weeks of twice‐daily transoral neuromuscular stimulation. Twenty patients completed the study: Sixteen males, mean ± SD age 40 ± 13 years, and BMI 26.3 ± 3.8 kg/m(2). Although there was no change in non‐rapid eye movement EMGgg phasic (p = 0.66) or tonic activity (p = 0.83), and no decrease in snoring or flow limitation, treatment was associated with improvements in tongue endurance, sleep quality, and sleep efficiency. In this protocol, transoral neurostimulation did not result in changes in genioglossal activity or upper airway collapse, but other beneficial effects were noted suggesting a need for additional mechanistic investigation. John Wiley and Sons Inc. 2022-06-24 /pmc/articles/PMC9226850/ /pubmed/35748091 http://dx.doi.org/10.14814/phy2.15360 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Nokes, Brandon Schmickl, Christopher N. Brena, Rebbecca Bosompra, Nana Naa‐Oye Gilbertson, Dillon Sands, Scott A. Bhattacharjee, Rakesh Mann, Dwayne L. Owens, Robert L. Malhotra, Atul Orr, Jeremy E. The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation |
title | The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation |
title_full | The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation |
title_fullStr | The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation |
title_full_unstemmed | The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation |
title_short | The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation |
title_sort | impact of daytime transoral neuromuscular stimulation on upper airway physiology – a mechanistic clinical investigation |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226850/ https://www.ncbi.nlm.nih.gov/pubmed/35748091 http://dx.doi.org/10.14814/phy2.15360 |
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