PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

BACKGROUND: The immune suppressive tumor microenvironment (TME) that inhibits T cell infiltration, survival, and antitumor activity has posed a major challenge for developing effective immunotherapies for solid tumors. Chimeric antigen receptor (CAR)-engineered T cell therapy has shown unprecedented...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Yukiko, Gibson, Jackson, Ou, Kevin, Lopez, Lupita S, Ng, Rachel H, Leggett, Neena, Jonsson, Vanessa D, Zarif, Jelani C, Lee, Peter P, Wang, Xiuli, Martinez, Catalina, Dorff, Tanya B, Forman, Stephen J, Priceman, Saul J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226933/
https://www.ncbi.nlm.nih.gov/pubmed/35738799
http://dx.doi.org/10.1136/jitc-2021-004400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226933/
https://www.ncbi.nlm.nih.gov/pubmed/35738799
http://dx.doi.org/10.1136/jitc-2021-004400

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