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Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

BACKGROUND: Adoptive cell therapy using cytotoxic lymphocytes is an efficient immunotherapy against solid and hematological cancers. However, elevated levels of reactive oxygen species (ROS) in the hostile tumor microenvironment can impair NK cell and T cell function. Auranofin, a gold (I)-containin...

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Detalles Bibliográficos
Autores principales:	Renken, Stefanie, Nakajima, Takahiro, Magalhaes, Isabelle, Mattsson, Jonas, Lundqvist, Andreas, Arnér, Elias S J, Kiessling, Rolf, Wickström, Stina Linnea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226989/ https://www.ncbi.nlm.nih.gov/pubmed/35738800 http://dx.doi.org/10.1136/jitc-2021-004458

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