Cargando…

Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France

Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large sca...

Descripción completa

Detalles Bibliográficos
Autores principales: Tardieu, Laurène, Divard, Gillian, Lortholary, Olivier, Scemla, Anne, Rondeau, Éric, Accoceberry, Isabelle, Agbonon, Rémi, Alanio, Alexandre, Angoulvant, Adela, Albano, Laetitia, Attias, Philippe, Bellanger, Anne Pauline, Bertrand, Dominique, Bonhomme, Julie, Botterel, Françoise, Bouvier, Nicolas, Buchler, Matthias, Chouaki, Taieb, Crépin, Thomas, Durieux, Marie-Fleur, Desoubeaux, Guillaume, Doppelt, Gary, Favennec, Loïc, Fekkar, Arnaud, Fourdinier, Ophélie, Frimat, Marie, Gangneux, Jean-Pierre, Garandeau, Claire, Hasseine, Lilia, Hennequin, Christophe, Iriart, Xavier, Kamar, Nassim, Kaminski, Hannah, Kormann, Raphael, Lachaud, Laurence, Legendre, Christophe, Le Quintrec Donnette, Moglie, Leroy, Jordan, Levi, Charlène, Machouart, Marie, Marx, David, Menotti, Jean, Moal, Valérie, Morio, Florent, Mrozek, Natacha, Nicolas, Muriel, Poirier, Philippe, Peraldi, Marie-Noelle, Poussot, Benjamin, Ranque, Stéphane, Rerolle, Jean-Philippe, Sendid, Boualem, Snanoudj, Renaud, Tourret, Jérôme, Vasse, Marc, Vigneau, Cécile, Villard, Odile, Mesnard, Laurent, Lanternier, Fanny, Rafat, Cédric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227085/
https://www.ncbi.nlm.nih.gov/pubmed/35745553
http://dx.doi.org/10.3390/pathogens11060699
_version_ 1784734075635892224
author Tardieu, Laurène
Divard, Gillian
Lortholary, Olivier
Scemla, Anne
Rondeau, Éric
Accoceberry, Isabelle
Agbonon, Rémi
Alanio, Alexandre
Angoulvant, Adela
Albano, Laetitia
Attias, Philippe
Bellanger, Anne Pauline
Bertrand, Dominique
Bonhomme, Julie
Botterel, Françoise
Bouvier, Nicolas
Buchler, Matthias
Chouaki, Taieb
Crépin, Thomas
Durieux, Marie-Fleur
Desoubeaux, Guillaume
Doppelt, Gary
Favennec, Loïc
Fekkar, Arnaud
Fourdinier, Ophélie
Frimat, Marie
Gangneux, Jean-Pierre
Garandeau, Claire
Hasseine, Lilia
Hennequin, Christophe
Iriart, Xavier
Kamar, Nassim
Kaminski, Hannah
Kormann, Raphael
Lachaud, Laurence
Legendre, Christophe
Le Quintrec Donnette, Moglie
Leroy, Jordan
Levi, Charlène
Machouart, Marie
Marx, David
Menotti, Jean
Moal, Valérie
Morio, Florent
Mrozek, Natacha
Nicolas, Muriel
Poirier, Philippe
Peraldi, Marie-Noelle
Poussot, Benjamin
Ranque, Stéphane
Rerolle, Jean-Philippe
Sendid, Boualem
Snanoudj, Renaud
Tourret, Jérôme
Vasse, Marc
Vigneau, Cécile
Villard, Odile
Mesnard, Laurent
Lanternier, Fanny
Rafat, Cédric
author_facet Tardieu, Laurène
Divard, Gillian
Lortholary, Olivier
Scemla, Anne
Rondeau, Éric
Accoceberry, Isabelle
Agbonon, Rémi
Alanio, Alexandre
Angoulvant, Adela
Albano, Laetitia
Attias, Philippe
Bellanger, Anne Pauline
Bertrand, Dominique
Bonhomme, Julie
Botterel, Françoise
Bouvier, Nicolas
Buchler, Matthias
Chouaki, Taieb
Crépin, Thomas
Durieux, Marie-Fleur
Desoubeaux, Guillaume
Doppelt, Gary
Favennec, Loïc
Fekkar, Arnaud
Fourdinier, Ophélie
Frimat, Marie
Gangneux, Jean-Pierre
Garandeau, Claire
Hasseine, Lilia
Hennequin, Christophe
Iriart, Xavier
Kamar, Nassim
Kaminski, Hannah
Kormann, Raphael
Lachaud, Laurence
Legendre, Christophe
Le Quintrec Donnette, Moglie
Leroy, Jordan
Levi, Charlène
Machouart, Marie
Marx, David
Menotti, Jean
Moal, Valérie
Morio, Florent
Mrozek, Natacha
Nicolas, Muriel
Poirier, Philippe
Peraldi, Marie-Noelle
Poussot, Benjamin
Ranque, Stéphane
Rerolle, Jean-Philippe
Sendid, Boualem
Snanoudj, Renaud
Tourret, Jérôme
Vasse, Marc
Vigneau, Cécile
Villard, Odile
Mesnard, Laurent
Lanternier, Fanny
Rafat, Cédric
author_sort Tardieu, Laurène
collection PubMed
description Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. We sought to describe overall and graft survival based on whether KT patients with cryptococcosis developed CM or not. Clinical indicators of CNS involvement and brain radiological characteristics were assessed. Eighty-eight cases of cryptococcosis were diagnosed during the study period, with 61 (69.3%) cases of CM. Mortality was high (32.8%) at 12 months (M12) but not significantly different whether or not patients presented with CM. Baseline hyponatremia and at least one neurological symptom were independently associated with CM (p < 0.001). Positive serum cryptococcal antigen at diagnosis was also significantly associated with CM (p < 0.001). On magnetic resonance imaging (MRI), three patterns of brain injury were identified: parenchymal, meningeal, and vascular lesions. Although CM does not affect graft function directly, it entails a grim prognosis.
format Online
Article
Text
id pubmed-9227085
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92270852022-06-25 Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France Tardieu, Laurène Divard, Gillian Lortholary, Olivier Scemla, Anne Rondeau, Éric Accoceberry, Isabelle Agbonon, Rémi Alanio, Alexandre Angoulvant, Adela Albano, Laetitia Attias, Philippe Bellanger, Anne Pauline Bertrand, Dominique Bonhomme, Julie Botterel, Françoise Bouvier, Nicolas Buchler, Matthias Chouaki, Taieb Crépin, Thomas Durieux, Marie-Fleur Desoubeaux, Guillaume Doppelt, Gary Favennec, Loïc Fekkar, Arnaud Fourdinier, Ophélie Frimat, Marie Gangneux, Jean-Pierre Garandeau, Claire Hasseine, Lilia Hennequin, Christophe Iriart, Xavier Kamar, Nassim Kaminski, Hannah Kormann, Raphael Lachaud, Laurence Legendre, Christophe Le Quintrec Donnette, Moglie Leroy, Jordan Levi, Charlène Machouart, Marie Marx, David Menotti, Jean Moal, Valérie Morio, Florent Mrozek, Natacha Nicolas, Muriel Poirier, Philippe Peraldi, Marie-Noelle Poussot, Benjamin Ranque, Stéphane Rerolle, Jean-Philippe Sendid, Boualem Snanoudj, Renaud Tourret, Jérôme Vasse, Marc Vigneau, Cécile Villard, Odile Mesnard, Laurent Lanternier, Fanny Rafat, Cédric Pathogens Article Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. We sought to describe overall and graft survival based on whether KT patients with cryptococcosis developed CM or not. Clinical indicators of CNS involvement and brain radiological characteristics were assessed. Eighty-eight cases of cryptococcosis were diagnosed during the study period, with 61 (69.3%) cases of CM. Mortality was high (32.8%) at 12 months (M12) but not significantly different whether or not patients presented with CM. Baseline hyponatremia and at least one neurological symptom were independently associated with CM (p < 0.001). Positive serum cryptococcal antigen at diagnosis was also significantly associated with CM (p < 0.001). On magnetic resonance imaging (MRI), three patterns of brain injury were identified: parenchymal, meningeal, and vascular lesions. Although CM does not affect graft function directly, it entails a grim prognosis. MDPI 2022-06-17 /pmc/articles/PMC9227085/ /pubmed/35745553 http://dx.doi.org/10.3390/pathogens11060699 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tardieu, Laurène
Divard, Gillian
Lortholary, Olivier
Scemla, Anne
Rondeau, Éric
Accoceberry, Isabelle
Agbonon, Rémi
Alanio, Alexandre
Angoulvant, Adela
Albano, Laetitia
Attias, Philippe
Bellanger, Anne Pauline
Bertrand, Dominique
Bonhomme, Julie
Botterel, Françoise
Bouvier, Nicolas
Buchler, Matthias
Chouaki, Taieb
Crépin, Thomas
Durieux, Marie-Fleur
Desoubeaux, Guillaume
Doppelt, Gary
Favennec, Loïc
Fekkar, Arnaud
Fourdinier, Ophélie
Frimat, Marie
Gangneux, Jean-Pierre
Garandeau, Claire
Hasseine, Lilia
Hennequin, Christophe
Iriart, Xavier
Kamar, Nassim
Kaminski, Hannah
Kormann, Raphael
Lachaud, Laurence
Legendre, Christophe
Le Quintrec Donnette, Moglie
Leroy, Jordan
Levi, Charlène
Machouart, Marie
Marx, David
Menotti, Jean
Moal, Valérie
Morio, Florent
Mrozek, Natacha
Nicolas, Muriel
Poirier, Philippe
Peraldi, Marie-Noelle
Poussot, Benjamin
Ranque, Stéphane
Rerolle, Jean-Philippe
Sendid, Boualem
Snanoudj, Renaud
Tourret, Jérôme
Vasse, Marc
Vigneau, Cécile
Villard, Odile
Mesnard, Laurent
Lanternier, Fanny
Rafat, Cédric
Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
title Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
title_full Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
title_fullStr Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
title_full_unstemmed Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
title_short Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
title_sort cryptococcal meningitis in kidney transplant recipients: a two-decade cohort study in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227085/
https://www.ncbi.nlm.nih.gov/pubmed/35745553
http://dx.doi.org/10.3390/pathogens11060699
work_keys_str_mv AT tardieulaurene cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT divardgillian cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT lortholaryolivier cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT scemlaanne cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT rondeaueric cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT accoceberryisabelle cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT agbononremi cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT alanioalexandre cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT angoulvantadela cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT albanolaetitia cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT attiasphilippe cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT bellangerannepauline cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT bertranddominique cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT bonhommejulie cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT botterelfrancoise cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT bouviernicolas cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT buchlermatthias cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT chouakitaieb cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT crepinthomas cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT durieuxmariefleur cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT desoubeauxguillaume cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT doppeltgary cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT favennecloic cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT fekkararnaud cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT fourdinierophelie cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT frimatmarie cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT gangneuxjeanpierre cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT garandeauclaire cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT hasseinelilia cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT hennequinchristophe cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT iriartxavier cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT kamarnassim cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT kaminskihannah cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT kormannraphael cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT lachaudlaurence cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT legendrechristophe cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT lequintrecdonnettemoglie cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT leroyjordan cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT levicharlene cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT machouartmarie cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT marxdavid cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT menottijean cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT moalvalerie cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT morioflorent cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT mrozeknatacha cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT nicolasmuriel cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT poirierphilippe cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT peraldimarienoelle cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT poussotbenjamin cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT ranquestephane cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT rerollejeanphilippe cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT sendidboualem cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT snanoudjrenaud cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT tourretjerome cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT vassemarc cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT vigneaucecile cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT villardodile cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT mesnardlaurent cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT lanternierfanny cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance
AT rafatcedric cryptococcalmeningitisinkidneytransplantrecipientsatwodecadecohortstudyinfrance