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Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans

We assessed longitudinal associations between plasma metabolites, their network-derived clusters, and type 2 diabetes (T2D) progression in Puerto Rican adults, a high-risk Hispanic subgroup with established health disparities. We used data from 1221 participants free of T2D and aged 40–75 years at b...

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Autores principales: Rivas-Tumanyan, Sona, Pacheco, Lorena S., Haslam, Danielle E., Liang, Liming, Tucker, Katherine L., Joshipura, Kaumudi J., Bhupathiraju, Shilpa N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227184/
https://www.ncbi.nlm.nih.gov/pubmed/35736445
http://dx.doi.org/10.3390/metabo12060513
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author Rivas-Tumanyan, Sona
Pacheco, Lorena S.
Haslam, Danielle E.
Liang, Liming
Tucker, Katherine L.
Joshipura, Kaumudi J.
Bhupathiraju, Shilpa N.
author_facet Rivas-Tumanyan, Sona
Pacheco, Lorena S.
Haslam, Danielle E.
Liang, Liming
Tucker, Katherine L.
Joshipura, Kaumudi J.
Bhupathiraju, Shilpa N.
author_sort Rivas-Tumanyan, Sona
collection PubMed
description We assessed longitudinal associations between plasma metabolites, their network-derived clusters, and type 2 diabetes (T2D) progression in Puerto Rican adults, a high-risk Hispanic subgroup with established health disparities. We used data from 1221 participants free of T2D and aged 40–75 years at baseline in the Boston Puerto Rican Health and San Juan Overweight Adult Longitudinal Studies. We used multivariable Poisson regression models to examine associations between baseline concentrations of metabolites and incident T2D and prediabetes. Cohort-specific estimates were combined using inverse-variance weighted fixed-effects meta-analyses. A cluster of 13 metabolites of branched chain amino acids (BCAA), and aromatic amino acid metabolism (pooled IRR = 1.87, 95% CI: 1.28; 2.73), and a cell membrane component metabolite cluster (pooled IRR = 1.54, 95% CI: 1.04; 2.27) were associated with a higher risk of incident T2D. When the metabolites were tested individually, in combined analysis, 5 metabolites involved in BCAA metabolism were associated with incident T2D. These findings highlight potential prognostic biomarkers to identify Puerto Rican adults who may be at high risk for diabetes. Future studies should examine whether diet and lifestyle can modify the associations between these metabolites and progression to T2D.
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spelling pubmed-92271842022-06-25 Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans Rivas-Tumanyan, Sona Pacheco, Lorena S. Haslam, Danielle E. Liang, Liming Tucker, Katherine L. Joshipura, Kaumudi J. Bhupathiraju, Shilpa N. Metabolites Article We assessed longitudinal associations between plasma metabolites, their network-derived clusters, and type 2 diabetes (T2D) progression in Puerto Rican adults, a high-risk Hispanic subgroup with established health disparities. We used data from 1221 participants free of T2D and aged 40–75 years at baseline in the Boston Puerto Rican Health and San Juan Overweight Adult Longitudinal Studies. We used multivariable Poisson regression models to examine associations between baseline concentrations of metabolites and incident T2D and prediabetes. Cohort-specific estimates were combined using inverse-variance weighted fixed-effects meta-analyses. A cluster of 13 metabolites of branched chain amino acids (BCAA), and aromatic amino acid metabolism (pooled IRR = 1.87, 95% CI: 1.28; 2.73), and a cell membrane component metabolite cluster (pooled IRR = 1.54, 95% CI: 1.04; 2.27) were associated with a higher risk of incident T2D. When the metabolites were tested individually, in combined analysis, 5 metabolites involved in BCAA metabolism were associated with incident T2D. These findings highlight potential prognostic biomarkers to identify Puerto Rican adults who may be at high risk for diabetes. Future studies should examine whether diet and lifestyle can modify the associations between these metabolites and progression to T2D. MDPI 2022-06-02 /pmc/articles/PMC9227184/ /pubmed/35736445 http://dx.doi.org/10.3390/metabo12060513 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rivas-Tumanyan, Sona
Pacheco, Lorena S.
Haslam, Danielle E.
Liang, Liming
Tucker, Katherine L.
Joshipura, Kaumudi J.
Bhupathiraju, Shilpa N.
Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans
title Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans
title_full Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans
title_fullStr Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans
title_full_unstemmed Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans
title_short Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans
title_sort novel plasma metabolomic markers associated with diabetes progression in older puerto ricans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227184/
https://www.ncbi.nlm.nih.gov/pubmed/35736445
http://dx.doi.org/10.3390/metabo12060513
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