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A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies

Snakebite being a quick progressing serious situation needs immediate and aggressive therapy. Snake venom antiserum is the only approved and effective treatment available, but for selected snake species only. The requirement of trained staff for administration and serum reactions make the therapy co...

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Autores principales: Deshpande, Adwait M., Sastry, K. Venkata, Bhise, Satish B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227218/
https://www.ncbi.nlm.nih.gov/pubmed/35736986
http://dx.doi.org/10.3390/tropicalmed7060108
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author Deshpande, Adwait M.
Sastry, K. Venkata
Bhise, Satish B.
author_facet Deshpande, Adwait M.
Sastry, K. Venkata
Bhise, Satish B.
author_sort Deshpande, Adwait M.
collection PubMed
description Snakebite being a quick progressing serious situation needs immediate and aggressive therapy. Snake venom antiserum is the only approved and effective treatment available, but for selected snake species only. The requirement of trained staff for administration and serum reactions make the therapy complicated. In tropical countries where snakebite incidence is high and healthcare facilities are limited, mortality and morbidities associated with snake envenomation are proportionately high. Traditional compilations of medical practitioners’ personal journals have wealth of plant-based snake venom antidotes. Relatively, very few plants or their extractives have been scientifically investigated for neutralization of snake venom or its components. None of these investigations presents enough evidence to initiate clinical testing of the agents. This review focuses on curating Indian traditional snake envenomation therapies, identifying plants involved and finding relevant evidence across modern literature to neutralize snake venom components. Traditional formulations, their method of preparation and dosing have been discussed along with the investigational approach in modern research and their possible outcomes. A safe and easily administrable small molecule of plant origin that would protect or limit the spread of venom and provide valuable time for the victim to reach the healthcare centre would be a great lifesaver.
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spelling pubmed-92272182022-06-25 A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies Deshpande, Adwait M. Sastry, K. Venkata Bhise, Satish B. Trop Med Infect Dis Review Snakebite being a quick progressing serious situation needs immediate and aggressive therapy. Snake venom antiserum is the only approved and effective treatment available, but for selected snake species only. The requirement of trained staff for administration and serum reactions make the therapy complicated. In tropical countries where snakebite incidence is high and healthcare facilities are limited, mortality and morbidities associated with snake envenomation are proportionately high. Traditional compilations of medical practitioners’ personal journals have wealth of plant-based snake venom antidotes. Relatively, very few plants or their extractives have been scientifically investigated for neutralization of snake venom or its components. None of these investigations presents enough evidence to initiate clinical testing of the agents. This review focuses on curating Indian traditional snake envenomation therapies, identifying plants involved and finding relevant evidence across modern literature to neutralize snake venom components. Traditional formulations, their method of preparation and dosing have been discussed along with the investigational approach in modern research and their possible outcomes. A safe and easily administrable small molecule of plant origin that would protect or limit the spread of venom and provide valuable time for the victim to reach the healthcare centre would be a great lifesaver. MDPI 2022-06-16 /pmc/articles/PMC9227218/ /pubmed/35736986 http://dx.doi.org/10.3390/tropicalmed7060108 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Deshpande, Adwait M.
Sastry, K. Venkata
Bhise, Satish B.
A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies
title A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies
title_full A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies
title_fullStr A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies
title_full_unstemmed A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies
title_short A Contemporary Exploration of Traditional Indian Snake Envenomation Therapies
title_sort contemporary exploration of traditional indian snake envenomation therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227218/
https://www.ncbi.nlm.nih.gov/pubmed/35736986
http://dx.doi.org/10.3390/tropicalmed7060108
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