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Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex

The intrinsic histone acetyltransferase (HAT), p300, has an important role in the development and progression of heart failure. Curcumin (CUR), a natural p300-specific HAT inhibitor, suppresses hypertrophic responses and prevents deterioration of left-ventricular systolic function in heart-failure m...

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Detalles Bibliográficos
Autores principales:	Funamoto, Masafumi, Sunagawa, Yoichi, Gempei, Mai, Shimizu, Kana, Katanasaka, Yasufumi, Shimizu, Satoshi, Hamabe-Horiike, Toshihide, Appendino, Giovanni, Minassi, Alberto, Koeberle, Andreas, Komiyama, Maki, Mori, Kiyoshi, Hasegawa, Koji, Morimoto, Tatsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227296/ https://www.ncbi.nlm.nih.gov/pubmed/35745840 http://dx.doi.org/10.3390/pharmaceutics14061269

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