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The Role of Saponins in the Treatment of Neuropathic Pain

Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient’s body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepile...

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Detalles Bibliográficos
Autores principales: Tan, Bei, Wu, Xueqing, Yu, Jie, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227328/
https://www.ncbi.nlm.nih.gov/pubmed/35745079
http://dx.doi.org/10.3390/molecules27123956
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author Tan, Bei
Wu, Xueqing
Yu, Jie
Chen, Zhong
author_facet Tan, Bei
Wu, Xueqing
Yu, Jie
Chen, Zhong
author_sort Tan, Bei
collection PubMed
description Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient’s body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepileptic drugs, or analgesics, often have limited efficacy and non-negligible side effects. As a bioactive and therapeutic component extracted from Chinese herbal medicine, the role of the effective compounds in the prevention and treatment of neuropathic pain have gradually become a research focus to explore new analgesics. Notably, saponins have shown analgesic effects in a large number of animal models. In this review, we summarized the most updated information of saponins, related to their analgesic effects in neuropathic pain, and the recent progress on the research of therapeutic targets and the potential mechanisms. Furthermore, we put up with some perspectives on future investigation to reveal the precise role of saponins in neuropathic pain.
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spelling pubmed-92273282022-06-25 The Role of Saponins in the Treatment of Neuropathic Pain Tan, Bei Wu, Xueqing Yu, Jie Chen, Zhong Molecules Review Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient’s body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepileptic drugs, or analgesics, often have limited efficacy and non-negligible side effects. As a bioactive and therapeutic component extracted from Chinese herbal medicine, the role of the effective compounds in the prevention and treatment of neuropathic pain have gradually become a research focus to explore new analgesics. Notably, saponins have shown analgesic effects in a large number of animal models. In this review, we summarized the most updated information of saponins, related to their analgesic effects in neuropathic pain, and the recent progress on the research of therapeutic targets and the potential mechanisms. Furthermore, we put up with some perspectives on future investigation to reveal the precise role of saponins in neuropathic pain. MDPI 2022-06-20 /pmc/articles/PMC9227328/ /pubmed/35745079 http://dx.doi.org/10.3390/molecules27123956 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tan, Bei
Wu, Xueqing
Yu, Jie
Chen, Zhong
The Role of Saponins in the Treatment of Neuropathic Pain
title The Role of Saponins in the Treatment of Neuropathic Pain
title_full The Role of Saponins in the Treatment of Neuropathic Pain
title_fullStr The Role of Saponins in the Treatment of Neuropathic Pain
title_full_unstemmed The Role of Saponins in the Treatment of Neuropathic Pain
title_short The Role of Saponins in the Treatment of Neuropathic Pain
title_sort role of saponins in the treatment of neuropathic pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227328/
https://www.ncbi.nlm.nih.gov/pubmed/35745079
http://dx.doi.org/10.3390/molecules27123956
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