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The Role of Saponins in the Treatment of Neuropathic Pain
Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient’s body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepile...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227328/ https://www.ncbi.nlm.nih.gov/pubmed/35745079 http://dx.doi.org/10.3390/molecules27123956 |
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author | Tan, Bei Wu, Xueqing Yu, Jie Chen, Zhong |
author_facet | Tan, Bei Wu, Xueqing Yu, Jie Chen, Zhong |
author_sort | Tan, Bei |
collection | PubMed |
description | Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient’s body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepileptic drugs, or analgesics, often have limited efficacy and non-negligible side effects. As a bioactive and therapeutic component extracted from Chinese herbal medicine, the role of the effective compounds in the prevention and treatment of neuropathic pain have gradually become a research focus to explore new analgesics. Notably, saponins have shown analgesic effects in a large number of animal models. In this review, we summarized the most updated information of saponins, related to their analgesic effects in neuropathic pain, and the recent progress on the research of therapeutic targets and the potential mechanisms. Furthermore, we put up with some perspectives on future investigation to reveal the precise role of saponins in neuropathic pain. |
format | Online Article Text |
id | pubmed-9227328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92273282022-06-25 The Role of Saponins in the Treatment of Neuropathic Pain Tan, Bei Wu, Xueqing Yu, Jie Chen, Zhong Molecules Review Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient’s body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepileptic drugs, or analgesics, often have limited efficacy and non-negligible side effects. As a bioactive and therapeutic component extracted from Chinese herbal medicine, the role of the effective compounds in the prevention and treatment of neuropathic pain have gradually become a research focus to explore new analgesics. Notably, saponins have shown analgesic effects in a large number of animal models. In this review, we summarized the most updated information of saponins, related to their analgesic effects in neuropathic pain, and the recent progress on the research of therapeutic targets and the potential mechanisms. Furthermore, we put up with some perspectives on future investigation to reveal the precise role of saponins in neuropathic pain. MDPI 2022-06-20 /pmc/articles/PMC9227328/ /pubmed/35745079 http://dx.doi.org/10.3390/molecules27123956 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tan, Bei Wu, Xueqing Yu, Jie Chen, Zhong The Role of Saponins in the Treatment of Neuropathic Pain |
title | The Role of Saponins in the Treatment of Neuropathic Pain |
title_full | The Role of Saponins in the Treatment of Neuropathic Pain |
title_fullStr | The Role of Saponins in the Treatment of Neuropathic Pain |
title_full_unstemmed | The Role of Saponins in the Treatment of Neuropathic Pain |
title_short | The Role of Saponins in the Treatment of Neuropathic Pain |
title_sort | role of saponins in the treatment of neuropathic pain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227328/ https://www.ncbi.nlm.nih.gov/pubmed/35745079 http://dx.doi.org/10.3390/molecules27123956 |
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