Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors

Recently, indocyanine green (ICG), as an FDA-approved dye, has been widely used for phototherapy. It is essential to obtain information on the migration and aggregation of ICG in deep tissues. However, existing fluorescence imaging platforms are not able to obtain the structural information of the t...

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Autores principales: Sun, Xin, Shan, Han, Lin, Qibo, Chen, Ziyan, Liu, Dongxu, Liu, Zhankai, Peng, Kuan, Chen, Zeyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227349/
https://www.ncbi.nlm.nih.gov/pubmed/35744560
http://dx.doi.org/10.3390/mi13060946
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author Sun, Xin
Shan, Han
Lin, Qibo
Chen, Ziyan
Liu, Dongxu
Liu, Zhankai
Peng, Kuan
Chen, Zeyu
author_facet Sun, Xin
Shan, Han
Lin, Qibo
Chen, Ziyan
Liu, Dongxu
Liu, Zhankai
Peng, Kuan
Chen, Zeyu
author_sort Sun, Xin
collection PubMed
description Recently, indocyanine green (ICG), as an FDA-approved dye, has been widely used for phototherapy. It is essential to obtain information on the migration and aggregation of ICG in deep tissues. However, existing fluorescence imaging platforms are not able to obtain the structural information of the tissues. Here, we prepared ICG liposomes (ICG-Lips) and built a dual-wavelength photoacoustic computed tomography (PACT) system with piezoelectric ring-array transducer to image the aggregation of ICG-Lips in tumors to guide phototherapy. Visible 780 nm light excited the photoacoustic (PA) effects of the ICG-Lips and near-infrared 1064 nm light provided the imaging of the surrounding tissues. The aggregation of ICG-Lips within the tumor and the surrounding tissues was visualized by PACT in real time. This work indicates that PACT with piezoelectric ring-array transducer has great potential in the real-time monitoring of in vivo drug distribution.
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spelling pubmed-92273492022-06-25 Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors Sun, Xin Shan, Han Lin, Qibo Chen, Ziyan Liu, Dongxu Liu, Zhankai Peng, Kuan Chen, Zeyu Micromachines (Basel) Article Recently, indocyanine green (ICG), as an FDA-approved dye, has been widely used for phototherapy. It is essential to obtain information on the migration and aggregation of ICG in deep tissues. However, existing fluorescence imaging platforms are not able to obtain the structural information of the tissues. Here, we prepared ICG liposomes (ICG-Lips) and built a dual-wavelength photoacoustic computed tomography (PACT) system with piezoelectric ring-array transducer to image the aggregation of ICG-Lips in tumors to guide phototherapy. Visible 780 nm light excited the photoacoustic (PA) effects of the ICG-Lips and near-infrared 1064 nm light provided the imaging of the surrounding tissues. The aggregation of ICG-Lips within the tumor and the surrounding tissues was visualized by PACT in real time. This work indicates that PACT with piezoelectric ring-array transducer has great potential in the real-time monitoring of in vivo drug distribution. MDPI 2022-06-15 /pmc/articles/PMC9227349/ /pubmed/35744560 http://dx.doi.org/10.3390/mi13060946 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Xin
Shan, Han
Lin, Qibo
Chen, Ziyan
Liu, Dongxu
Liu, Zhankai
Peng, Kuan
Chen, Zeyu
Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors
title Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors
title_full Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors
title_fullStr Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors
title_full_unstemmed Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors
title_short Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors
title_sort dual-wavelength photoacoustic computed tomography with piezoelectric ring-array transducer for imaging of indocyanine green liposomes aggregation in tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227349/
https://www.ncbi.nlm.nih.gov/pubmed/35744560
http://dx.doi.org/10.3390/mi13060946
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