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Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study

Introduction: Given the impact of COVID-19 on the world healthcare system, and the efforts of the healthcare community to find prognostic factors for hospitalization, disease progression, and mortality, the aim of the present study was to investigate the prognostic impact of transaminases and biliru...

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Autores principales: Russo, Antonio, Pisaturo, Mariantonietta, Palladino, Roberta, Maggi, Paolo, Numis, Fabio Giuliano, Gentile, Ivan, Sangiovanni, Vincenzo, Esposito, Vincenzo, Punzi, Rodolfo, Calabria, Giosuele, Rescigno, Carolina, Salomone Megna, Angelo, Masullo, Alfonso, Manzillo, Elio, Russo, Grazia, Parrella, Roberto, Dell’Aquila, Giuseppina, Gambardella, Michele, Ponticiello, Antonio, Coppola, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227474/
https://www.ncbi.nlm.nih.gov/pubmed/35745506
http://dx.doi.org/10.3390/pathogens11060652
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author Russo, Antonio
Pisaturo, Mariantonietta
Palladino, Roberta
Maggi, Paolo
Numis, Fabio Giuliano
Gentile, Ivan
Sangiovanni, Vincenzo
Esposito, Vincenzo
Punzi, Rodolfo
Calabria, Giosuele
Rescigno, Carolina
Salomone Megna, Angelo
Masullo, Alfonso
Manzillo, Elio
Russo, Grazia
Parrella, Roberto
Dell’Aquila, Giuseppina
Gambardella, Michele
Ponticiello, Antonio
Coppola, Nicola
author_facet Russo, Antonio
Pisaturo, Mariantonietta
Palladino, Roberta
Maggi, Paolo
Numis, Fabio Giuliano
Gentile, Ivan
Sangiovanni, Vincenzo
Esposito, Vincenzo
Punzi, Rodolfo
Calabria, Giosuele
Rescigno, Carolina
Salomone Megna, Angelo
Masullo, Alfonso
Manzillo, Elio
Russo, Grazia
Parrella, Roberto
Dell’Aquila, Giuseppina
Gambardella, Michele
Ponticiello, Antonio
Coppola, Nicola
author_sort Russo, Antonio
collection PubMed
description Introduction: Given the impact of COVID-19 on the world healthcare system, and the efforts of the healthcare community to find prognostic factors for hospitalization, disease progression, and mortality, the aim of the present study was to investigate the prognostic impact of transaminases and bilirubin levels at admission to hospital on disease progression and mortality in COVID-19 patients. Methods: Using the CoviCamp database, we performed a multicenter, observational, retrospective study involving 17 COVID-19 Units in southern Italy. We included all adult patients hospitalized for SARS-CoV-2 infection with at least one determination at hospital admission of aminotransaminases and/or total bilirubin. Results: Of the 2054 patients included in the CoviCamp database, 1641 were included in our study; 789 patients (48%) were considered to have mild COVID-19, 347 (21%) moderate COVID-19, 354 (22%) severe COVID-19, and 151 patients (9%) died during hospitalization. Older age (odds ratio (OR): 1.02; 95% confidence interval (CI) 1.01–1.03), higher Charlson comorbidity index (CCI) (OR 1.088; 95%CI 1.005–1.18), presence of dementia (OR: 2.20; 95% CI: 1.30–3.73), higher serum AST (OR: 1.002; 95% CI: 1.0001–1.004), and total bilirubin (OR: 1.09; 95% CI: 1.002–1.19) values were associated with a more severe clinical outcome. Instead, the 151 patients who died during hospitalization showed a higher serum bilirubin value at admission (OR 1.1165; 95% CI: 1.017–1.335); the same did not apply for AST. Discussion: Patients with COVID-19 with higher levels of AST and bilirubin had an increased risk of disease progression.
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spelling pubmed-92274742022-06-25 Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study Russo, Antonio Pisaturo, Mariantonietta Palladino, Roberta Maggi, Paolo Numis, Fabio Giuliano Gentile, Ivan Sangiovanni, Vincenzo Esposito, Vincenzo Punzi, Rodolfo Calabria, Giosuele Rescigno, Carolina Salomone Megna, Angelo Masullo, Alfonso Manzillo, Elio Russo, Grazia Parrella, Roberto Dell’Aquila, Giuseppina Gambardella, Michele Ponticiello, Antonio Coppola, Nicola Pathogens Article Introduction: Given the impact of COVID-19 on the world healthcare system, and the efforts of the healthcare community to find prognostic factors for hospitalization, disease progression, and mortality, the aim of the present study was to investigate the prognostic impact of transaminases and bilirubin levels at admission to hospital on disease progression and mortality in COVID-19 patients. Methods: Using the CoviCamp database, we performed a multicenter, observational, retrospective study involving 17 COVID-19 Units in southern Italy. We included all adult patients hospitalized for SARS-CoV-2 infection with at least one determination at hospital admission of aminotransaminases and/or total bilirubin. Results: Of the 2054 patients included in the CoviCamp database, 1641 were included in our study; 789 patients (48%) were considered to have mild COVID-19, 347 (21%) moderate COVID-19, 354 (22%) severe COVID-19, and 151 patients (9%) died during hospitalization. Older age (odds ratio (OR): 1.02; 95% confidence interval (CI) 1.01–1.03), higher Charlson comorbidity index (CCI) (OR 1.088; 95%CI 1.005–1.18), presence of dementia (OR: 2.20; 95% CI: 1.30–3.73), higher serum AST (OR: 1.002; 95% CI: 1.0001–1.004), and total bilirubin (OR: 1.09; 95% CI: 1.002–1.19) values were associated with a more severe clinical outcome. Instead, the 151 patients who died during hospitalization showed a higher serum bilirubin value at admission (OR 1.1165; 95% CI: 1.017–1.335); the same did not apply for AST. Discussion: Patients with COVID-19 with higher levels of AST and bilirubin had an increased risk of disease progression. MDPI 2022-06-06 /pmc/articles/PMC9227474/ /pubmed/35745506 http://dx.doi.org/10.3390/pathogens11060652 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Russo, Antonio
Pisaturo, Mariantonietta
Palladino, Roberta
Maggi, Paolo
Numis, Fabio Giuliano
Gentile, Ivan
Sangiovanni, Vincenzo
Esposito, Vincenzo
Punzi, Rodolfo
Calabria, Giosuele
Rescigno, Carolina
Salomone Megna, Angelo
Masullo, Alfonso
Manzillo, Elio
Russo, Grazia
Parrella, Roberto
Dell’Aquila, Giuseppina
Gambardella, Michele
Ponticiello, Antonio
Coppola, Nicola
Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study
title Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study
title_full Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study
title_fullStr Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study
title_full_unstemmed Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study
title_short Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study
title_sort prognostic value of transaminases and bilirubin levels at admission to hospital on disease progression and mortality in patients with covid-19—an observational retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227474/
https://www.ncbi.nlm.nih.gov/pubmed/35745506
http://dx.doi.org/10.3390/pathogens11060652
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