Cargando…

Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective

A significant amount of attention has recently been devoted to the mechanisms involved in hemoglobin (Hb) switching, as it has previously been established that the induction of fetal hemoglobin (HbF) production in significant amounts can reduce the severity of the clinical course in diseases such as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bou-Fakhredin, Rayan, De Franceschi, Lucia, Motta, Irene, Cappellini, Maria Domenica, Taher, Ali T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227505/ https://www.ncbi.nlm.nih.gov/pubmed/35745672 http://dx.doi.org/10.3390/ph15060753

Ejemplares similares

Redox Balance in β-Thalassemia and Sickle Cell Disease: A Love and Hate Relationship
por: Bou-Fakhredin, Rayan, et al.
Publicado: (2022)

Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation
por: Motta, Irene, et al.
Publicado: (2020)

Non-Transfusion-Dependent Thalassemia: An Update on Complications and Management
por: Sleiman, Joseph, et al.
Publicado: (2018)

Iron Overload and Chelation Therapy in Non-Transfusion Dependent Thalassemia
por: Bou-Fakhredin, Rayan, et al.
Publicado: (2017)

Deferasirox: Over a Decade of Experience in Thalassemia
por: Moukalled, Nour M., et al.
Publicado: (2018)

CYP450 Mediates Reactive Oxygen Species Production in a Mouse Model of β-Thalassemia through an Increase in 20-HETE Activity
por: Bou-Fakhredin, Rayan, et al.
Publicado: (2021)

Therapeutic perspective for children and young adults living with thalassemia and sickle cell disease
por: Ferraresi, Marta, et al.
Publicado: (2023)

EHA Research Roadmap on Hemoglobinopathies and Thalassemia: An Update
por: Iolascon, Achille, et al.
Publicado: (2019)

MicroRNA Expression in β-Thalassemia and Sickle Cell Disease: A Role in The Induction of Fetal Hemoglobin
por: Saki, Najmaldin, et al.
Publicado: (2016)

Thalassemia in the emergency department: special considerations for a rare disease
por: Saliba, Antoine N., et al.
Publicado: (2020)

Coagulopathy in Beta-Thalassemia: Current Understanding and Future Perspectives
por: Cappellini, M. Domenica, et al.
Publicado: (2009)

Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia—Current Status and Perspectives in Fetal Hemoglobin Reactivation
por: Ng, Noel Yat Hey, et al.
Publicado: (2014)

A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs
por: Prosdocimi, Marco, et al.
Publicado: (2022)

Right in time: Mitapivat for the treatment of anemia in α- and β-thalassemia
por: Musallam, Khaled M., et al.
Publicado: (2022)

Sickle Cell Disease and Fetal Hemoglobin
por: Rivera, Alicia
Publicado: (2018)

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production
por: Zuccato, Cristina, et al.
Publicado: (2021)

β-Thalassemia: New Therapeutic Modalities, Genetics, Complications, and Quality of Life
por: Karimi, Mehran, et al.
Publicado: (2012)

Treating iron overload in patients with non-transfusion-dependent thalassemia
por: Taher, Ali T, et al.
Publicado: (2013)

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
por: Lu, Dian, et al.
Publicado: (2022)

Advances in hemoglobin disorders
por: Cappellini, Maria Domenica
Publicado: (2018)

Update on the use of deferasirox in the management of iron overload
por: Taher, Ali, et al.
Publicado: (2009)

Fetal hemoglobin and hemolysis markers in sickle cell anemia()
por: Colella, Marina Pereira, et al.
Publicado: (2015)

2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia
por: Farmakis, Dimitrios, et al.
Publicado: (2022)

Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of β-Thalassemia and Sickle-Cell Anemia
por: Bianchi, Nicoletta, et al.
Publicado: (2009)

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
por: Zuccato, Cristina, et al.
Publicado: (2012)

Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β(0)-thalassemia/hemoglobin E erythroid cells
por: Kaewsakulthong, Woratree, et al.
Publicado: (2021)

Luspatercept for transfusion-dependent β-thalassemia: time to get real
por: Musallam, Khaled M., et al.
Publicado: (2023)

Deep venous thrombosis and pulmonary embolism after COVID-19 mRNA vaccination
por: Atoui, Ali, et al.
Publicado: (2022)

Manifestation of paroxysmal nocturnal hemoglobinuria after COVID-19 mRNA vaccination
por: Jarrah, Kawthar, et al.
Publicado: (2022)

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease
por: El Hoss, Sara, et al.
Publicado: (2020)

Significance of heme oxygenase-1(HMOX1) gene on fetal hemoglobin induction in sickle cell anemia patients
por: Hariharan, Priya, et al.
Publicado: (2020)

Recommendations for Pregnancy in Rare Inherited Anemias
por: Taher, Ali T., et al.
Publicado: (2020)

Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with nontransfusion-dependent thalassemia syndromes
por: Taher, Ali T, et al.
Publicado: (2016)

Updates of the HbVar database of human hemoglobin variants and thalassemia mutations
por: Giardine, Belinda, et al.
Publicado: (2014)

Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients
por: Breda, Laura, et al.
Publicado: (2012)

Fetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia
por: Eridani, Sandro, et al.
Publicado: (2011)

Fetal hemoglobin level and nutritional status in patients with sickle cell disease
por: Badawy, Sherif M.
Publicado: (2016)

Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes
por: Steinberg, Martin H.
Publicado: (2020)

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION
por: Lipucci di Paola, M.L.P., et al.
Publicado: (2023)

Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β(0)-thalassemia/HbE erythroid cells
por: Chumchuen, Sukanya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_14fvv07109uj2j968ka5opoaor