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Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil

Essential oils contain many volatile compounds that are not stable and lose their pharmacological effect when exposed to the environment. The aim of this study is to protect Boswellia serrata L. essential oil from environmental factors by encapsulation and determine the influence of chitosan concent...

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Autores principales: Pudziuvelyte, Lauryna, Siauruseviciute, Aiste, Morkuniene, Ramune, Lazauskas, Robertas, Bernatoniene, Jurga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227605/
https://www.ncbi.nlm.nih.gov/pubmed/35745831
http://dx.doi.org/10.3390/pharmaceutics14061259
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author Pudziuvelyte, Lauryna
Siauruseviciute, Aiste
Morkuniene, Ramune
Lazauskas, Robertas
Bernatoniene, Jurga
author_facet Pudziuvelyte, Lauryna
Siauruseviciute, Aiste
Morkuniene, Ramune
Lazauskas, Robertas
Bernatoniene, Jurga
author_sort Pudziuvelyte, Lauryna
collection PubMed
description Essential oils contain many volatile compounds that are not stable and lose their pharmacological effect when exposed to the environment. The aim of this study is to protect Boswellia serrata L. essential oil from environmental factors by encapsulation and determine the influence of chitosan concentration and types (2%, 4%; medium and high molecular weights), essential oil concentration, different emulsifiers (Tween and Span), and technological factors (stirring time, launch height, drip rate) on the physical parameters, morphology, texture, and other parameters of the generated gels, emulsions, and microcapsules. For the first time, Boswellia serrata L. essential oil microcapsules with chitosan were prepared by coacervation. Hardness, consistency, stickiness, viscosity, and pH of chitosan gels were tested. Freshly obtained microcapsules were examined for moisture, hardness, resistance to compression, size, and morphology. Results show that different molecular weights and concentrations of chitosan affected gel hardness, consistency, stickiness, viscosity, mobility, and adhesion. An increase in chitosan concentration from 2% to 4% significantly changed the appearance of the microcapsules. It was found that spherical microcapsules were formed when using MMW and HMW 80/1000 chitosan. Chitosan molecular weight, concentration, essential oil concentration, and stirring time all had an impact on the hardness of the microcapsules and their resistance to compression.
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spelling pubmed-92276052022-06-25 Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil Pudziuvelyte, Lauryna Siauruseviciute, Aiste Morkuniene, Ramune Lazauskas, Robertas Bernatoniene, Jurga Pharmaceutics Article Essential oils contain many volatile compounds that are not stable and lose their pharmacological effect when exposed to the environment. The aim of this study is to protect Boswellia serrata L. essential oil from environmental factors by encapsulation and determine the influence of chitosan concentration and types (2%, 4%; medium and high molecular weights), essential oil concentration, different emulsifiers (Tween and Span), and technological factors (stirring time, launch height, drip rate) on the physical parameters, morphology, texture, and other parameters of the generated gels, emulsions, and microcapsules. For the first time, Boswellia serrata L. essential oil microcapsules with chitosan were prepared by coacervation. Hardness, consistency, stickiness, viscosity, and pH of chitosan gels were tested. Freshly obtained microcapsules were examined for moisture, hardness, resistance to compression, size, and morphology. Results show that different molecular weights and concentrations of chitosan affected gel hardness, consistency, stickiness, viscosity, mobility, and adhesion. An increase in chitosan concentration from 2% to 4% significantly changed the appearance of the microcapsules. It was found that spherical microcapsules were formed when using MMW and HMW 80/1000 chitosan. Chitosan molecular weight, concentration, essential oil concentration, and stirring time all had an impact on the hardness of the microcapsules and their resistance to compression. MDPI 2022-06-13 /pmc/articles/PMC9227605/ /pubmed/35745831 http://dx.doi.org/10.3390/pharmaceutics14061259 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pudziuvelyte, Lauryna
Siauruseviciute, Aiste
Morkuniene, Ramune
Lazauskas, Robertas
Bernatoniene, Jurga
Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
title Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
title_full Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
title_fullStr Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
title_full_unstemmed Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
title_short Influence of Technological Factors on the Quality of Chitosan Microcapsules with Boswellia serata L. Essential Oil
title_sort influence of technological factors on the quality of chitosan microcapsules with boswellia serata l. essential oil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227605/
https://www.ncbi.nlm.nih.gov/pubmed/35745831
http://dx.doi.org/10.3390/pharmaceutics14061259
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