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Establishment of Level a In Vitro–In Vivo Correlation (IVIVC) via Extended DoE-IVIVC Model: A Donepezil Case Study
This study aimed to establish an extended design of experiment (DoE)-in vitro in vivo correlation (IVIVC) model that defines the relationship between formulation composition, in vitro dissolution, and in vivo pharmacokinetics. Fourteen sustained-release (SR) tablets of a model drug, donepezil, were...
Autores principales: | Lee, Da Young, Shin, Soyoung, Kim, Tae Hwan, Shin, Beom Soo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227873/ https://www.ncbi.nlm.nih.gov/pubmed/35745798 http://dx.doi.org/10.3390/pharmaceutics14061226 |
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