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Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227897/ https://www.ncbi.nlm.nih.gov/pubmed/35736659 http://dx.doi.org/10.3390/pediatric14020037 |
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author | Magazzù, Giuseppe Aquilina, Samuel Barbara, Christopher Bondin, Ramon Brusca, Ignazio Bugeja, Jacqueline Camilleri, Mark Cascio, Donato Costa, Stefano Cuzzupè, Chiara Duca, Annalise Fregapane, Maria Gentile, Vito Giuliano, Angele Grifò, Alessia Grima, Anne-Marie Ieni, Antonio Li Calzi, Giada Maisano, Fabiana Melita, Giuseppinella Pallio, Socrate Panasiti, Ilenia Pellegrino, Salvatore Romano, Claudio Sorce, Salvatore Tabacchi, Marco Elio Taormina, Vincenzo Tegolo, Domenico Tortora, Andrea Valenti, Cesare Vella, Cecil Raso, Giuseppe |
author_facet | Magazzù, Giuseppe Aquilina, Samuel Barbara, Christopher Bondin, Ramon Brusca, Ignazio Bugeja, Jacqueline Camilleri, Mark Cascio, Donato Costa, Stefano Cuzzupè, Chiara Duca, Annalise Fregapane, Maria Gentile, Vito Giuliano, Angele Grifò, Alessia Grima, Anne-Marie Ieni, Antonio Li Calzi, Giada Maisano, Fabiana Melita, Giuseppinella Pallio, Socrate Panasiti, Ilenia Pellegrino, Salvatore Romano, Claudio Sorce, Salvatore Tabacchi, Marco Elio Taormina, Vincenzo Tegolo, Domenico Tortora, Andrea Valenti, Cesare Vella, Cecil Raso, Giuseppe |
author_sort | Magazzù, Giuseppe |
collection | PubMed |
description | Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate the need for intestinal biopsy. Moreover, this study delves deeper into the “coeliac iceberg” in an attempt to identify people with disorders who may benefit from a gluten-free diet, even in the absence of gastrointestinal symptoms, abnormal serology and histology. This was achieved by looking for TGA-IgA mucosal deposits in duodenal biopsy. This large European multidisciplinary health project paves the way to an improved quality of life for patients by reducing the costs for diagnosis due to delayed findings of CD and to offer business opportunities in terms of diagnostic tools and support. |
format | Online Article Text |
id | pubmed-9227897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92278972022-06-25 Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol Magazzù, Giuseppe Aquilina, Samuel Barbara, Christopher Bondin, Ramon Brusca, Ignazio Bugeja, Jacqueline Camilleri, Mark Cascio, Donato Costa, Stefano Cuzzupè, Chiara Duca, Annalise Fregapane, Maria Gentile, Vito Giuliano, Angele Grifò, Alessia Grima, Anne-Marie Ieni, Antonio Li Calzi, Giada Maisano, Fabiana Melita, Giuseppinella Pallio, Socrate Panasiti, Ilenia Pellegrino, Salvatore Romano, Claudio Sorce, Salvatore Tabacchi, Marco Elio Taormina, Vincenzo Tegolo, Domenico Tortora, Andrea Valenti, Cesare Vella, Cecil Raso, Giuseppe Pediatr Rep Study Protocol Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate the need for intestinal biopsy. Moreover, this study delves deeper into the “coeliac iceberg” in an attempt to identify people with disorders who may benefit from a gluten-free diet, even in the absence of gastrointestinal symptoms, abnormal serology and histology. This was achieved by looking for TGA-IgA mucosal deposits in duodenal biopsy. This large European multidisciplinary health project paves the way to an improved quality of life for patients by reducing the costs for diagnosis due to delayed findings of CD and to offer business opportunities in terms of diagnostic tools and support. MDPI 2022-06-10 /pmc/articles/PMC9227897/ /pubmed/35736659 http://dx.doi.org/10.3390/pediatric14020037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Study Protocol Magazzù, Giuseppe Aquilina, Samuel Barbara, Christopher Bondin, Ramon Brusca, Ignazio Bugeja, Jacqueline Camilleri, Mark Cascio, Donato Costa, Stefano Cuzzupè, Chiara Duca, Annalise Fregapane, Maria Gentile, Vito Giuliano, Angele Grifò, Alessia Grima, Anne-Marie Ieni, Antonio Li Calzi, Giada Maisano, Fabiana Melita, Giuseppinella Pallio, Socrate Panasiti, Ilenia Pellegrino, Salvatore Romano, Claudio Sorce, Salvatore Tabacchi, Marco Elio Taormina, Vincenzo Tegolo, Domenico Tortora, Andrea Valenti, Cesare Vella, Cecil Raso, Giuseppe Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol |
title | Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol |
title_full | Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol |
title_fullStr | Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol |
title_full_unstemmed | Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol |
title_short | Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol |
title_sort | recognizing the emergent and submerged iceberg of the celiac disease: itama project—global strategy protocol |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227897/ https://www.ncbi.nlm.nih.gov/pubmed/35736659 http://dx.doi.org/10.3390/pediatric14020037 |
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