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Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol

Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the...

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Autores principales: Magazzù, Giuseppe, Aquilina, Samuel, Barbara, Christopher, Bondin, Ramon, Brusca, Ignazio, Bugeja, Jacqueline, Camilleri, Mark, Cascio, Donato, Costa, Stefano, Cuzzupè, Chiara, Duca, Annalise, Fregapane, Maria, Gentile, Vito, Giuliano, Angele, Grifò, Alessia, Grima, Anne-Marie, Ieni, Antonio, Li Calzi, Giada, Maisano, Fabiana, Melita, Giuseppinella, Pallio, Socrate, Panasiti, Ilenia, Pellegrino, Salvatore, Romano, Claudio, Sorce, Salvatore, Tabacchi, Marco Elio, Taormina, Vincenzo, Tegolo, Domenico, Tortora, Andrea, Valenti, Cesare, Vella, Cecil, Raso, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227897/
https://www.ncbi.nlm.nih.gov/pubmed/35736659
http://dx.doi.org/10.3390/pediatric14020037
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author Magazzù, Giuseppe
Aquilina, Samuel
Barbara, Christopher
Bondin, Ramon
Brusca, Ignazio
Bugeja, Jacqueline
Camilleri, Mark
Cascio, Donato
Costa, Stefano
Cuzzupè, Chiara
Duca, Annalise
Fregapane, Maria
Gentile, Vito
Giuliano, Angele
Grifò, Alessia
Grima, Anne-Marie
Ieni, Antonio
Li Calzi, Giada
Maisano, Fabiana
Melita, Giuseppinella
Pallio, Socrate
Panasiti, Ilenia
Pellegrino, Salvatore
Romano, Claudio
Sorce, Salvatore
Tabacchi, Marco Elio
Taormina, Vincenzo
Tegolo, Domenico
Tortora, Andrea
Valenti, Cesare
Vella, Cecil
Raso, Giuseppe
author_facet Magazzù, Giuseppe
Aquilina, Samuel
Barbara, Christopher
Bondin, Ramon
Brusca, Ignazio
Bugeja, Jacqueline
Camilleri, Mark
Cascio, Donato
Costa, Stefano
Cuzzupè, Chiara
Duca, Annalise
Fregapane, Maria
Gentile, Vito
Giuliano, Angele
Grifò, Alessia
Grima, Anne-Marie
Ieni, Antonio
Li Calzi, Giada
Maisano, Fabiana
Melita, Giuseppinella
Pallio, Socrate
Panasiti, Ilenia
Pellegrino, Salvatore
Romano, Claudio
Sorce, Salvatore
Tabacchi, Marco Elio
Taormina, Vincenzo
Tegolo, Domenico
Tortora, Andrea
Valenti, Cesare
Vella, Cecil
Raso, Giuseppe
author_sort Magazzù, Giuseppe
collection PubMed
description Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate the need for intestinal biopsy. Moreover, this study delves deeper into the “coeliac iceberg” in an attempt to identify people with disorders who may benefit from a gluten-free diet, even in the absence of gastrointestinal symptoms, abnormal serology and histology. This was achieved by looking for TGA-IgA mucosal deposits in duodenal biopsy. This large European multidisciplinary health project paves the way to an improved quality of life for patients by reducing the costs for diagnosis due to delayed findings of CD and to offer business opportunities in terms of diagnostic tools and support.
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spelling pubmed-92278972022-06-25 Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol Magazzù, Giuseppe Aquilina, Samuel Barbara, Christopher Bondin, Ramon Brusca, Ignazio Bugeja, Jacqueline Camilleri, Mark Cascio, Donato Costa, Stefano Cuzzupè, Chiara Duca, Annalise Fregapane, Maria Gentile, Vito Giuliano, Angele Grifò, Alessia Grima, Anne-Marie Ieni, Antonio Li Calzi, Giada Maisano, Fabiana Melita, Giuseppinella Pallio, Socrate Panasiti, Ilenia Pellegrino, Salvatore Romano, Claudio Sorce, Salvatore Tabacchi, Marco Elio Taormina, Vincenzo Tegolo, Domenico Tortora, Andrea Valenti, Cesare Vella, Cecil Raso, Giuseppe Pediatr Rep Study Protocol Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate the need for intestinal biopsy. Moreover, this study delves deeper into the “coeliac iceberg” in an attempt to identify people with disorders who may benefit from a gluten-free diet, even in the absence of gastrointestinal symptoms, abnormal serology and histology. This was achieved by looking for TGA-IgA mucosal deposits in duodenal biopsy. This large European multidisciplinary health project paves the way to an improved quality of life for patients by reducing the costs for diagnosis due to delayed findings of CD and to offer business opportunities in terms of diagnostic tools and support. MDPI 2022-06-10 /pmc/articles/PMC9227897/ /pubmed/35736659 http://dx.doi.org/10.3390/pediatric14020037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
Magazzù, Giuseppe
Aquilina, Samuel
Barbara, Christopher
Bondin, Ramon
Brusca, Ignazio
Bugeja, Jacqueline
Camilleri, Mark
Cascio, Donato
Costa, Stefano
Cuzzupè, Chiara
Duca, Annalise
Fregapane, Maria
Gentile, Vito
Giuliano, Angele
Grifò, Alessia
Grima, Anne-Marie
Ieni, Antonio
Li Calzi, Giada
Maisano, Fabiana
Melita, Giuseppinella
Pallio, Socrate
Panasiti, Ilenia
Pellegrino, Salvatore
Romano, Claudio
Sorce, Salvatore
Tabacchi, Marco Elio
Taormina, Vincenzo
Tegolo, Domenico
Tortora, Andrea
Valenti, Cesare
Vella, Cecil
Raso, Giuseppe
Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
title Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
title_full Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
title_fullStr Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
title_full_unstemmed Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
title_short Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
title_sort recognizing the emergent and submerged iceberg of the celiac disease: itama project—global strategy protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227897/
https://www.ncbi.nlm.nih.gov/pubmed/35736659
http://dx.doi.org/10.3390/pediatric14020037
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