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Natural Immunity against HIV-1: Progression of Understanding after Association Studies
Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natura...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227919/ https://www.ncbi.nlm.nih.gov/pubmed/35746714 http://dx.doi.org/10.3390/v14061243 |
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author | Luo, Ma |
author_facet | Luo, Ma |
author_sort | Luo, Ma |
collection | PubMed |
description | Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natural immunity to HIV in the hope to develop effective vaccines and preventions. This review focuses on two such examples. These studies started from identifying immunogenetic or genetic associations with resistance to HIV acquisition, and followed up with an in-depth investigation to understand the biological relevance of the correlations of protection, and to develop and test novel vaccines and preventions. |
format | Online Article Text |
id | pubmed-9227919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92279192022-06-25 Natural Immunity against HIV-1: Progression of Understanding after Association Studies Luo, Ma Viruses Review Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natural immunity to HIV in the hope to develop effective vaccines and preventions. This review focuses on two such examples. These studies started from identifying immunogenetic or genetic associations with resistance to HIV acquisition, and followed up with an in-depth investigation to understand the biological relevance of the correlations of protection, and to develop and test novel vaccines and preventions. MDPI 2022-06-08 /pmc/articles/PMC9227919/ /pubmed/35746714 http://dx.doi.org/10.3390/v14061243 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Luo, Ma Natural Immunity against HIV-1: Progression of Understanding after Association Studies |
title | Natural Immunity against HIV-1: Progression of Understanding after Association Studies |
title_full | Natural Immunity against HIV-1: Progression of Understanding after Association Studies |
title_fullStr | Natural Immunity against HIV-1: Progression of Understanding after Association Studies |
title_full_unstemmed | Natural Immunity against HIV-1: Progression of Understanding after Association Studies |
title_short | Natural Immunity against HIV-1: Progression of Understanding after Association Studies |
title_sort | natural immunity against hiv-1: progression of understanding after association studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227919/ https://www.ncbi.nlm.nih.gov/pubmed/35746714 http://dx.doi.org/10.3390/v14061243 |
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