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Natural Immunity against HIV-1: Progression of Understanding after Association Studies

Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natura...

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Autor principal: Luo, Ma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227919/
https://www.ncbi.nlm.nih.gov/pubmed/35746714
http://dx.doi.org/10.3390/v14061243
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author Luo, Ma
author_facet Luo, Ma
author_sort Luo, Ma
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description Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natural immunity to HIV in the hope to develop effective vaccines and preventions. This review focuses on two such examples. These studies started from identifying immunogenetic or genetic associations with resistance to HIV acquisition, and followed up with an in-depth investigation to understand the biological relevance of the correlations of protection, and to develop and test novel vaccines and preventions.
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spelling pubmed-92279192022-06-25 Natural Immunity against HIV-1: Progression of Understanding after Association Studies Luo, Ma Viruses Review Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natural immunity to HIV in the hope to develop effective vaccines and preventions. This review focuses on two such examples. These studies started from identifying immunogenetic or genetic associations with resistance to HIV acquisition, and followed up with an in-depth investigation to understand the biological relevance of the correlations of protection, and to develop and test novel vaccines and preventions. MDPI 2022-06-08 /pmc/articles/PMC9227919/ /pubmed/35746714 http://dx.doi.org/10.3390/v14061243 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Luo, Ma
Natural Immunity against HIV-1: Progression of Understanding after Association Studies
title Natural Immunity against HIV-1: Progression of Understanding after Association Studies
title_full Natural Immunity against HIV-1: Progression of Understanding after Association Studies
title_fullStr Natural Immunity against HIV-1: Progression of Understanding after Association Studies
title_full_unstemmed Natural Immunity against HIV-1: Progression of Understanding after Association Studies
title_short Natural Immunity against HIV-1: Progression of Understanding after Association Studies
title_sort natural immunity against hiv-1: progression of understanding after association studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227919/
https://www.ncbi.nlm.nih.gov/pubmed/35746714
http://dx.doi.org/10.3390/v14061243
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