Cargando…

Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice

Taurine is a sulfated amino acid derivative that plays an important role in maintaining the cell function of the living body. Although taurine has been shown to ameliorate diabetes, its mechanism of action has not yet been fully elucidated. The present study investigated the effects of taurine on di...

Descripción completa

Detalles Bibliográficos
Autores principales: Murakami, Shigeru, Funahashi, Kohei, Tamagawa, Natsuki, Ning, Ma, Ito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228042/
https://www.ncbi.nlm.nih.gov/pubmed/35736457
http://dx.doi.org/10.3390/metabo12060524
_version_ 1784734336397869056
author Murakami, Shigeru
Funahashi, Kohei
Tamagawa, Natsuki
Ning, Ma
Ito, Takashi
author_facet Murakami, Shigeru
Funahashi, Kohei
Tamagawa, Natsuki
Ning, Ma
Ito, Takashi
author_sort Murakami, Shigeru
collection PubMed
description Taurine is a sulfated amino acid derivative that plays an important role in maintaining the cell function of the living body. Although taurine has been shown to ameliorate diabetes, its mechanism of action has not yet been fully elucidated. The present study investigated the effects of taurine on diabetes focusing on glucose metabolism and oxidative stress. Type 1 diabetes was induced by the administration of streptozotocin (STZ) to male C57BL/6J mice. Taurine was dissolved in drinking water at 3% (w/v) and allowed to be freely ingested by diabetic mice. The weight and blood glucose levels were measured weekly. After nine weeks, mice were sacrificed and their serum, liver, and kidney were removed and used for biochemical and histological analyses. A microarray analysis was also performed in normal mice. Taurine alleviated STZ-induced hyperglycemia and hyperketonemia, accompanied by the suppression of the decrease in hepatic glycogen and upregulation of the mRNA expression of hepatic glucose transporter GLUT-2. Furthermore, STZ-induced elevation of oxidative stress in the liver and kidney was suppressed by taurine treatment. These results showed that taurine ameliorated diabetes and diabetic complications by improving hepatic glucose metabolism and reducing oxidative stress.
format Online
Article
Text
id pubmed-9228042
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92280422022-06-25 Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice Murakami, Shigeru Funahashi, Kohei Tamagawa, Natsuki Ning, Ma Ito, Takashi Metabolites Article Taurine is a sulfated amino acid derivative that plays an important role in maintaining the cell function of the living body. Although taurine has been shown to ameliorate diabetes, its mechanism of action has not yet been fully elucidated. The present study investigated the effects of taurine on diabetes focusing on glucose metabolism and oxidative stress. Type 1 diabetes was induced by the administration of streptozotocin (STZ) to male C57BL/6J mice. Taurine was dissolved in drinking water at 3% (w/v) and allowed to be freely ingested by diabetic mice. The weight and blood glucose levels were measured weekly. After nine weeks, mice were sacrificed and their serum, liver, and kidney were removed and used for biochemical and histological analyses. A microarray analysis was also performed in normal mice. Taurine alleviated STZ-induced hyperglycemia and hyperketonemia, accompanied by the suppression of the decrease in hepatic glycogen and upregulation of the mRNA expression of hepatic glucose transporter GLUT-2. Furthermore, STZ-induced elevation of oxidative stress in the liver and kidney was suppressed by taurine treatment. These results showed that taurine ameliorated diabetes and diabetic complications by improving hepatic glucose metabolism and reducing oxidative stress. MDPI 2022-06-06 /pmc/articles/PMC9228042/ /pubmed/35736457 http://dx.doi.org/10.3390/metabo12060524 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Murakami, Shigeru
Funahashi, Kohei
Tamagawa, Natsuki
Ning, Ma
Ito, Takashi
Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice
title Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice
title_full Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice
title_fullStr Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice
title_full_unstemmed Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice
title_short Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice
title_sort taurine ameliorates streptozotocin-induced diabetes by modulating hepatic glucose metabolism and oxidative stress in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228042/
https://www.ncbi.nlm.nih.gov/pubmed/35736457
http://dx.doi.org/10.3390/metabo12060524
work_keys_str_mv AT murakamishigeru taurineamelioratesstreptozotocininduceddiabetesbymodulatinghepaticglucosemetabolismandoxidativestressinmice
AT funahashikohei taurineamelioratesstreptozotocininduceddiabetesbymodulatinghepaticglucosemetabolismandoxidativestressinmice
AT tamagawanatsuki taurineamelioratesstreptozotocininduceddiabetesbymodulatinghepaticglucosemetabolismandoxidativestressinmice
AT ningma taurineamelioratesstreptozotocininduceddiabetesbymodulatinghepaticglucosemetabolismandoxidativestressinmice
AT itotakashi taurineamelioratesstreptozotocininduceddiabetesbymodulatinghepaticglucosemetabolismandoxidativestressinmice