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What Drives Radical Halogenation versus Hydroxylation in Mononuclear Nonheme Iron Complexes? A Combined Experimental and Computational Study

[Image: see text] Nonheme iron halogenases are unique enzymes in nature that selectively activate an aliphatic C–H bond of a substrate to convert it into C–X (X = Cl/Br, but not F/I). It is proposed that they generate an Fe(III)(OH)(X) intermediate in their catalytic cycle. The analogous Fe(III)(OH)...

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Detalles Bibliográficos
Autores principales:	Gérard, Emilie F., Yadav, Vishal, Goldberg, David P., de Visser, Sam P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228086/ https://www.ncbi.nlm.nih.gov/pubmed/35537044 http://dx.doi.org/10.1021/jacs.2c01375

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