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Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology

Terahertz (THz) radiation has attracted wide attention in recent years due to its non-destructive properties and ability to sense molecular structures. In applications combining terahertz radiation with metamaterial technology, the interaction between the terahertz radiation and the metamaterials ca...

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Autores principales: Lin, Yen-Shuo, Huang, Shih-Ting, Hsu, Shen-Fu Steve, Tang, Kai-Yuan, Yen, Ta-Jen, Yao, Da-Jeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228199/
https://www.ncbi.nlm.nih.gov/pubmed/35744518
http://dx.doi.org/10.3390/mi13060904
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author Lin, Yen-Shuo
Huang, Shih-Ting
Hsu, Shen-Fu Steve
Tang, Kai-Yuan
Yen, Ta-Jen
Yao, Da-Jeng
author_facet Lin, Yen-Shuo
Huang, Shih-Ting
Hsu, Shen-Fu Steve
Tang, Kai-Yuan
Yen, Ta-Jen
Yao, Da-Jeng
author_sort Lin, Yen-Shuo
collection PubMed
description Terahertz (THz) radiation has attracted wide attention in recent years due to its non-destructive properties and ability to sense molecular structures. In applications combining terahertz radiation with metamaterial technology, the interaction between the terahertz radiation and the metamaterials causes resonance reactions; different analytes have different resonance performances in the frequency domain. In addition, a microfluidic system is able to provide low volume reagents for detection, reduce noise from the environment, and concentrate the sample on the detection area. Through simulation, a cruciform metamaterial pattern was designed; the proportion, periodicity, and width of the metamaterial were adjusted to improve the sensing capability of the chip. In the experiments, the sensing capabilities of Type A, B, and C chips were compared. The Type C chip had the most significant resonant effect; its maximum shift could be increased to 89 GHz. In the probiotic experiment, the cruciform chip could have a 0.72 GHz shift at a concentration of 0.025 mg/50 μL, confirming that terahertz radiation combined with a metamaterial microfluidic chip can perform low-concentration detection.
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spelling pubmed-92281992022-06-25 Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology Lin, Yen-Shuo Huang, Shih-Ting Hsu, Shen-Fu Steve Tang, Kai-Yuan Yen, Ta-Jen Yao, Da-Jeng Micromachines (Basel) Article Terahertz (THz) radiation has attracted wide attention in recent years due to its non-destructive properties and ability to sense molecular structures. In applications combining terahertz radiation with metamaterial technology, the interaction between the terahertz radiation and the metamaterials causes resonance reactions; different analytes have different resonance performances in the frequency domain. In addition, a microfluidic system is able to provide low volume reagents for detection, reduce noise from the environment, and concentrate the sample on the detection area. Through simulation, a cruciform metamaterial pattern was designed; the proportion, periodicity, and width of the metamaterial were adjusted to improve the sensing capability of the chip. In the experiments, the sensing capabilities of Type A, B, and C chips were compared. The Type C chip had the most significant resonant effect; its maximum shift could be increased to 89 GHz. In the probiotic experiment, the cruciform chip could have a 0.72 GHz shift at a concentration of 0.025 mg/50 μL, confirming that terahertz radiation combined with a metamaterial microfluidic chip can perform low-concentration detection. MDPI 2022-06-07 /pmc/articles/PMC9228199/ /pubmed/35744518 http://dx.doi.org/10.3390/mi13060904 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Yen-Shuo
Huang, Shih-Ting
Hsu, Shen-Fu Steve
Tang, Kai-Yuan
Yen, Ta-Jen
Yao, Da-Jeng
Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology
title Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology
title_full Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology
title_fullStr Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology
title_full_unstemmed Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology
title_short Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology
title_sort sensitivity enhancement and probiotic detection of microfluidic chips based on terahertz radiation combined with metamaterial technology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228199/
https://www.ncbi.nlm.nih.gov/pubmed/35744518
http://dx.doi.org/10.3390/mi13060904
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