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Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19

COVID-19 infection may lead to serious complications, e.g., need for mechanical ventilation or death in some cases. A retrospective analysis of patients referred to our COVID Emergency Department, indiscriminately, was performed. A routine lab analysis measured amino acids in plasma and urine of pat...

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Autores principales: Bánfai, Gábor, Kanizsai, Péter, Csontos, Csaba, Kun, Szilárd, Lakatos, Ágnes, Lajtai, Anikó, Lelovics, Vanessza, Szukits, Sándor, Bogner, Péter, Miseta, Attila, Wittmann, István, Molnár, Gergő A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228241/
https://www.ncbi.nlm.nih.gov/pubmed/35736419
http://dx.doi.org/10.3390/metabo12060486
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author Bánfai, Gábor
Kanizsai, Péter
Csontos, Csaba
Kun, Szilárd
Lakatos, Ágnes
Lajtai, Anikó
Lelovics, Vanessza
Szukits, Sándor
Bogner, Péter
Miseta, Attila
Wittmann, István
Molnár, Gergő A.
author_facet Bánfai, Gábor
Kanizsai, Péter
Csontos, Csaba
Kun, Szilárd
Lakatos, Ágnes
Lajtai, Anikó
Lelovics, Vanessza
Szukits, Sándor
Bogner, Péter
Miseta, Attila
Wittmann, István
Molnár, Gergő A.
author_sort Bánfai, Gábor
collection PubMed
description COVID-19 infection may lead to serious complications, e.g., need for mechanical ventilation or death in some cases. A retrospective analysis of patients referred to our COVID Emergency Department, indiscriminately, was performed. A routine lab analysis measured amino acids in plasma and urine of patients. Data of surviving and deceased patients and those requiring or not requiring mechanical ventilation were compared, and logistic regression analyses have been performed. Deceased patients were older, had higher blood glucose, potassium, AST, LDH, troponin, d-dimer, hsCRP, procalcitonin, interleukin-6 levels (p < 0.05 for all). They had lower plasma serine, glycine, threonine, tryptophan levels (p < 0.01), higher tyrosine and phenylalanine levels (p < 0.05), and higher fractional excretion of arginine, methionine, and proline (p < 0.05) than survivors. In a regression model, age, severity score of COVID-pneumonia, plasma levels of threonine and phenylalanine were predictors of in-hospital mortality. There was a difference in ventilated vs. non-ventilated patients in CT-scores, glucose, and renal function (p < 0.001). Using logistic regression, CT-score, troponin, plasma level, and fractional excretion of glycine were predictors of ventilation. Plasma levels and renal excretion of certain amino acids are associated with the outcome of COVID-19 infection beside other parameters such as the CT-score or age.
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spelling pubmed-92282412022-06-25 Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19 Bánfai, Gábor Kanizsai, Péter Csontos, Csaba Kun, Szilárd Lakatos, Ágnes Lajtai, Anikó Lelovics, Vanessza Szukits, Sándor Bogner, Péter Miseta, Attila Wittmann, István Molnár, Gergő A. Metabolites Article COVID-19 infection may lead to serious complications, e.g., need for mechanical ventilation or death in some cases. A retrospective analysis of patients referred to our COVID Emergency Department, indiscriminately, was performed. A routine lab analysis measured amino acids in plasma and urine of patients. Data of surviving and deceased patients and those requiring or not requiring mechanical ventilation were compared, and logistic regression analyses have been performed. Deceased patients were older, had higher blood glucose, potassium, AST, LDH, troponin, d-dimer, hsCRP, procalcitonin, interleukin-6 levels (p < 0.05 for all). They had lower plasma serine, glycine, threonine, tryptophan levels (p < 0.01), higher tyrosine and phenylalanine levels (p < 0.05), and higher fractional excretion of arginine, methionine, and proline (p < 0.05) than survivors. In a regression model, age, severity score of COVID-pneumonia, plasma levels of threonine and phenylalanine were predictors of in-hospital mortality. There was a difference in ventilated vs. non-ventilated patients in CT-scores, glucose, and renal function (p < 0.001). Using logistic regression, CT-score, troponin, plasma level, and fractional excretion of glycine were predictors of ventilation. Plasma levels and renal excretion of certain amino acids are associated with the outcome of COVID-19 infection beside other parameters such as the CT-score or age. MDPI 2022-05-27 /pmc/articles/PMC9228241/ /pubmed/35736419 http://dx.doi.org/10.3390/metabo12060486 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bánfai, Gábor
Kanizsai, Péter
Csontos, Csaba
Kun, Szilárd
Lakatos, Ágnes
Lajtai, Anikó
Lelovics, Vanessza
Szukits, Sándor
Bogner, Péter
Miseta, Attila
Wittmann, István
Molnár, Gergő A.
Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19
title Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19
title_full Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19
title_fullStr Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19
title_full_unstemmed Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19
title_short Plasma Levels and Renal Handling of Amino Acids Contribute to Determination of Risk of Mortality or Feed of Ventilation in Patients with COVID-19
title_sort plasma levels and renal handling of amino acids contribute to determination of risk of mortality or feed of ventilation in patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228241/
https://www.ncbi.nlm.nih.gov/pubmed/35736419
http://dx.doi.org/10.3390/metabo12060486
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