Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structures of well-known kinase inhibitors and our previou...

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Detalles Bibliográficos
Autores principales: Bertrand, Jeanluc, Dostálová, Hana, Kryštof, Vladimír, Jorda, Radek, Delgado, Thalía, Castro-Alvarez, Alejandro, Mella, Jaime, Cabezas, David, Faúndez, Mario, Espinosa-Bustos, Christian, Salas, Cristian O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228270/
https://www.ncbi.nlm.nih.gov/pubmed/35745866
http://dx.doi.org/10.3390/pharmaceutics14061294

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