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Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease()
BACKGROUND: Brain-computer interface (BCI) systems are controlled by users through neurophysiological input for a variety of applications, including communication, environmental control, and motor rehabilitation. Although individuals with severe speech and physical impairment are the primary users o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228283/ https://www.ncbi.nlm.nih.gov/pubmed/35754975 http://dx.doi.org/10.1016/j.conctc.2022.100950 |
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author | Galvin-McLaughlin, Deirdre Klee, Daniel Memmott, Tab Peters, Betts Wiedrick, Jack Fried-Oken, Melanie Oken, Barry |
author_facet | Galvin-McLaughlin, Deirdre Klee, Daniel Memmott, Tab Peters, Betts Wiedrick, Jack Fried-Oken, Melanie Oken, Barry |
author_sort | Galvin-McLaughlin, Deirdre |
collection | PubMed |
description | BACKGROUND: Brain-computer interface (BCI) systems are controlled by users through neurophysiological input for a variety of applications, including communication, environmental control, and motor rehabilitation. Although individuals with severe speech and physical impairment are the primary users of this technology, BCIs have emerged as a potential tool for broader populations, including delivering cognitive training/interventions with neurofeedback (NFB). METHODS: This paper describes the development and preliminary testing of a protocol for use of a BCI system with NFB as an intervention for people with mild Alzheimer's disease (AD). The intervention focused on training visual attention and language skills, as AD is often associated with functional impairments in both. This funded pilot study called for enrolling five participants with mild AD in a six-week BCI EEG-based NFB intervention that followed a four-to-seven-week baseline phase. While two participants completed the study, the remaining three participants could not complete the intervention phase because of COVID-19 restrictions. RESULTS: Preliminary pilot results suggested: (1) participants with mild AD were able to participate in a study with multiple assessments per week and complete all outcome measures, (2) most outcome measures were reliable during the baseline phase, and (3) all participants with mild AD learned to operate a BCI spelling system with training. CONCLUSIONS: Although preliminary results demonstrate practical feasibility to deliver NFB intervention using a BCI to adults with AD, completion of the protocol in its entirety with more participants is needed to further assess whether implementing NFB-based cognitive intervention is justified by functional treatment outcomes. TRIAL REGISTRATION: This study was registered with ClinicalTrials.gov (NCT03790774). |
format | Online Article Text |
id | pubmed-9228283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92282832022-06-25 Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() Galvin-McLaughlin, Deirdre Klee, Daniel Memmott, Tab Peters, Betts Wiedrick, Jack Fried-Oken, Melanie Oken, Barry Contemp Clin Trials Commun Article BACKGROUND: Brain-computer interface (BCI) systems are controlled by users through neurophysiological input for a variety of applications, including communication, environmental control, and motor rehabilitation. Although individuals with severe speech and physical impairment are the primary users of this technology, BCIs have emerged as a potential tool for broader populations, including delivering cognitive training/interventions with neurofeedback (NFB). METHODS: This paper describes the development and preliminary testing of a protocol for use of a BCI system with NFB as an intervention for people with mild Alzheimer's disease (AD). The intervention focused on training visual attention and language skills, as AD is often associated with functional impairments in both. This funded pilot study called for enrolling five participants with mild AD in a six-week BCI EEG-based NFB intervention that followed a four-to-seven-week baseline phase. While two participants completed the study, the remaining three participants could not complete the intervention phase because of COVID-19 restrictions. RESULTS: Preliminary pilot results suggested: (1) participants with mild AD were able to participate in a study with multiple assessments per week and complete all outcome measures, (2) most outcome measures were reliable during the baseline phase, and (3) all participants with mild AD learned to operate a BCI spelling system with training. CONCLUSIONS: Although preliminary results demonstrate practical feasibility to deliver NFB intervention using a BCI to adults with AD, completion of the protocol in its entirety with more participants is needed to further assess whether implementing NFB-based cognitive intervention is justified by functional treatment outcomes. TRIAL REGISTRATION: This study was registered with ClinicalTrials.gov (NCT03790774). Elsevier 2022-06-13 /pmc/articles/PMC9228283/ /pubmed/35754975 http://dx.doi.org/10.1016/j.conctc.2022.100950 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Galvin-McLaughlin, Deirdre Klee, Daniel Memmott, Tab Peters, Betts Wiedrick, Jack Fried-Oken, Melanie Oken, Barry Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() |
title | Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() |
title_full | Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() |
title_fullStr | Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() |
title_full_unstemmed | Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() |
title_short | Methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild Alzheimer's disease() |
title_sort | methodology and preliminary data on feasibility of a neurofeedback protocol to improve visual attention to letters in mild alzheimer's disease() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228283/ https://www.ncbi.nlm.nih.gov/pubmed/35754975 http://dx.doi.org/10.1016/j.conctc.2022.100950 |
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