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Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients

In the current pandemic of coronavirus disease (COVID-19), the identification of the patients admitted with severe infection–who are disposed to a high risk of acute respiratory distress syndrome (ARDS) development, is of a major significance for the determination of the appropriate therapeutic stra...

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Autores principales: Yovchevska, Iviana P., Trenovski, Alexandar B., Atanasova, Maria H., Georgiev, Martin N., Tafradjiiska-Hadjiolova, Radka K., Lazarov, Simeon D., Yovchevski, Plamen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228300/
https://www.ncbi.nlm.nih.gov/pubmed/35736647
http://dx.doi.org/10.3390/pathophysiology29020019
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author Yovchevska, Iviana P.
Trenovski, Alexandar B.
Atanasova, Maria H.
Georgiev, Martin N.
Tafradjiiska-Hadjiolova, Radka K.
Lazarov, Simeon D.
Yovchevski, Plamen H.
author_facet Yovchevska, Iviana P.
Trenovski, Alexandar B.
Atanasova, Maria H.
Georgiev, Martin N.
Tafradjiiska-Hadjiolova, Radka K.
Lazarov, Simeon D.
Yovchevski, Plamen H.
author_sort Yovchevska, Iviana P.
collection PubMed
description In the current pandemic of coronavirus disease (COVID-19), the identification of the patients admitted with severe infection–who are disposed to a high risk of acute respiratory distress syndrome (ARDS) development, is of a major significance for the determination of the appropriate therapeutic strategy. Laboratory records in admission were retrospectively reviewed from 493 cases of severe COVID-19 divided into two groups: Group 1 with ARDS and Group 2 without ARDS. The platelet distribution width (PDW) difference between Group 1 and Group 2 is significant–15.10 ± 2.08 fl for those who developed ARDS versus 12.94 ± 2.12 fl for those without ARDS. The sensitivity and the specificity of this parameter is lower than that of D-dimer. After grouping of the PDW values into intervals and combining them with the rate of increase in D-dimer (D-PDWf index) to form a forecasting index, a significant increase in the specificity and sensitivity of the two parameters is identified–area under the ROC curve (AUC) is 0.874 for D-PDWf index, with respective AUC for PDW 0.768 and AUC for D-dimer 0.777. Conclusion: PDW is a significant predictive parameter at admission for subsequent development of ARDS in patients, with increased significance in combination with the degree of increase in D-dimer.
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spelling pubmed-92283002022-06-25 Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients Yovchevska, Iviana P. Trenovski, Alexandar B. Atanasova, Maria H. Georgiev, Martin N. Tafradjiiska-Hadjiolova, Radka K. Lazarov, Simeon D. Yovchevski, Plamen H. Pathophysiology Article In the current pandemic of coronavirus disease (COVID-19), the identification of the patients admitted with severe infection–who are disposed to a high risk of acute respiratory distress syndrome (ARDS) development, is of a major significance for the determination of the appropriate therapeutic strategy. Laboratory records in admission were retrospectively reviewed from 493 cases of severe COVID-19 divided into two groups: Group 1 with ARDS and Group 2 without ARDS. The platelet distribution width (PDW) difference between Group 1 and Group 2 is significant–15.10 ± 2.08 fl for those who developed ARDS versus 12.94 ± 2.12 fl for those without ARDS. The sensitivity and the specificity of this parameter is lower than that of D-dimer. After grouping of the PDW values into intervals and combining them with the rate of increase in D-dimer (D-PDWf index) to form a forecasting index, a significant increase in the specificity and sensitivity of the two parameters is identified–area under the ROC curve (AUC) is 0.874 for D-PDWf index, with respective AUC for PDW 0.768 and AUC for D-dimer 0.777. Conclusion: PDW is a significant predictive parameter at admission for subsequent development of ARDS in patients, with increased significance in combination with the degree of increase in D-dimer. MDPI 2022-06-01 /pmc/articles/PMC9228300/ /pubmed/35736647 http://dx.doi.org/10.3390/pathophysiology29020019 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yovchevska, Iviana P.
Trenovski, Alexandar B.
Atanasova, Maria H.
Georgiev, Martin N.
Tafradjiiska-Hadjiolova, Radka K.
Lazarov, Simeon D.
Yovchevski, Plamen H.
Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
title Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
title_full Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
title_fullStr Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
title_full_unstemmed Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
title_short Platelet Distribution Width and Increased D-Dimer at Admission Predicts Subsequent Development of ARDS in COVID-19 Patients
title_sort platelet distribution width and increased d-dimer at admission predicts subsequent development of ards in covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228300/
https://www.ncbi.nlm.nih.gov/pubmed/35736647
http://dx.doi.org/10.3390/pathophysiology29020019
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