Simultaneous Characterization and Determination of Warfarin and Its Hydroxylation Metabolites in Rat Plasma by Chiral Liquid Chromatography-Tandem Mass Spectrometry

Warfarin is extensively used for venous thromboembolism and other coagulopathies. In clinical settings, warfarin is administered as a mixture of S- and R-warfarin, and both enantiomers are metabolized by multiple cytochrome P450 enzymes into many hydroxylation metabolites. Due to the high degree of...

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Detalles Bibliográficos
Autores principales: Jin, Shasha, Li, Zhihong, Yang, Qing, Fang, Boyu, Xiang, Xiaoqiang, Peng, Chao, Cai, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228315/
https://www.ncbi.nlm.nih.gov/pubmed/35745714
http://dx.doi.org/10.3390/pharmaceutics14061141

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